NEW SERIES. SERIES: PHYSICS
ISSN 1817-3020 (Print)
ISSN 2542-193X (Online)


Биофизика и медицинская физика

A MODEL FOR PARTICLE TRANSPORT IN BRANCHED BLOOD OR LYMPH VESSELS UNDER THE INFLUENCE OF MAGNETIC FIELD

A model has been developed to study the trajectory and capturing of particles transported in a bifurcation blood or lymph vessel under the influence of cylindrical permanent magnet that is located outside the vessel. Magnetic nanoparticles, such as Superparamagnetic iron Oxide Nanoparticles (Fe3O4) are used in this theoretical study. The magnet is placed at one of outlet branched vessel to attract the magnetic particles towards targeted locations. The fluid (blood or lymph) is assumed Newtonian; its flow is incompressible, laminar.

Modeling of Epidemics by Cellular Automata Lattices. SIRS Model with Reproduction and Migration

Background and Objectives: Methods of population dynamics give the possibility to analyze many biological phenomena by constructing simple qualitative models, which allow to understand their nature and to predict their behavior. This approach is used to study the spread of epidemics of infectious diseases in biological and human populations. The work considers a modified SIRS model of epidemic spread in the form of a lattice of stochastic cellular automata.

Toxicity of Upconversion Nanoparticles. Overview

Background and Objectives: The object of the study was the toxicity of upconversion nanoparticles. The aim is to overview the literature on the toxicity of various types of upconversion nanoparticles and to search for their maximum permissible concentration when administered to laboratory animals in vivo. Materials and Methods: The approach used has been the analysis of recent publications on the topic.

Measurement of Optical Properties of Human Gums and Dentin in the Spectral Range from 350 to 800 nm

Knowledge of the optical properties of biological tissues is important for the development of optical diagnostics, photodynamic and photothermal therapy of various diseases. However, despite the significant number of works devoted to the determination of the optical properties of tissues, the optical properties of human gums and dentin remain currently poorly understood. In this work, we experimentally studied the optical properties of human gums and dentin in the spectral range from 350 nm to 800 nm.

METHOD FOR DETERMINING SIGNIFICANT COMPONENTS FOR ASSESSING PULSE WAVE SHAPE VARIABILITY

Background and Objectives: The conventional approach to the quantification of the pulse wave is based on the assessment of the features of its shape within each beat to beat heart interval. Usually, a set of indices is calculated (such as heart efficiency index, reflection index, stiffness index), which are determined by the reference points of the wave contour. We have developed an alternative method aimed to analyze the variability of the pulse waveform regardless of the variability of its rhythm.

Conductive nanofibrous scaffolds for tissue engineering

One of very demanded and actively developed areas of modern biomedicine is tissue engineering, investigating synthesis and reparation of various kinds of tissues, including trauma treatment. Normally cells in tissue grow in the microenvironment provided by exttacellular matrix – a three-dimensional network of macromolecules, mostly peptides and proteins, that provide structural and biochemical support. To substitute this matrix in medical applications and promote new cells growth and repair damaged tissue, various types of artificial scaffolds are proposed.

SONOPHORETIC ACCELERATION OF DEGRADATION PROCESS FOR VATERITE PARTICLES DELIVERED INTO THE HAIR FOLLICLES

Intrafollicular drug delivery is beneficial in terms of both localized therapy of relevant skin disorders and systemic transportation of bioactive molecules. Vaterite particles are capable of loading and delivering various substances to hair follicles. Possibility to control the duration of their intrafollicular degradation can improve such a particulate delivery system. Here, we propose the use of sonophoresis (1 MHz, 1 W/cm2) to accelerate the resorption of vaterite carriers inside the hair follicles of rats in vivo.

ТОКСИЧНОСТЬ АПКОНВЕРСИОННЫХ НАНОЧАСТИЦ. ОБЗОР.

В работе приведен обзор результатов исследований по выявлению токсичности различных типов апконверсионных наночастиц. Апконверсионные частицы являются перспективными для визуализации структуры биологических тканей и органов в люминесцентном свете, а также для использования при диагностике заболеваний и фотоиндуцированной терапии. Рассмотрены наночастицы с дополнительными оболочками или функционализированные при помощи покрытия поверхности адресными или фотоактивными молекулами, позволяющими создание частиц с несколькими модальностями.

Estimation of the Value of Reverse Blood Flow in the Artery by the Second Derivative of the Pulse Pressure Wave

Background and Objectives: Previously, the diastolic section of the pulse wave was most often analyzed as the result of reflection of a direct wave from the elements of peripheral vessels. However, measurements of the negative linear velocity of blood flow using ultrasound dopplerograms clearly indicate the presence of reverse blood flow in the arteries. The aim of the work was to establish the relationship of the second derivative of the pulse pressure wave with the value of the reverse blood flow in the arterial bed.

Non-invasive Methods for in vivo Determination of the Skin Barrier Function – Advantages of Confocal Raman Microspectroscopy

The physical barrier of the stratum corneum (SC) is provided by corneocytes and the lateral organization of intercellular lipids, which necessarily includes the orthorhombic organization phase. A review of methods used for in vivo non-invasive measurement of skin barrier function has been carried out and it has been shown that all currently used methods are indirect. The most popular method is the measurement of the transepidermal water loss (TEWL), which does not provide information on biophysical parameters responsible for the barrier function of the SC.

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