Izvestiya of Saratov University.

Physics

ISSN 1817-3020 (Print)
ISSN 2542-193X (Online)

For citation:

Lengert E. V., Ermakov A. V., Ivanov A. N. Effect of electric field pulses on the suspension of microcontainers based on organic polymer and magnetite nanoparticles. Izvestiya of Saratov University. Physics , 2021, vol. 21, iss. 3, pp. 206-212. DOI: 10.18500/1817-3020-2021-21-3-206-212, EDN: OWZNYY

This is an open access article distributed under the terms of Creative Commons Attribution 4.0 International License (CC-BY 4.0).
Published online: 
31.08.2021
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Language: 
English
Heading: 
Biophysics and medical physics
Article type: 
Article
UDC: 
53.06:53.04:544
DOI: 
10.18500/1817-3020-2021-21-3-206-212
EDN: 
OWZNYY

Effect of electric field pulses on the suspension of microcontainers based on organic polymer and magnetite nanoparticles

Autors: 
Lengert Ekaterina Vladimirovna, Saratov State Medical University named after V. I. Razumovsky
Ermakov Alexey Vadimovich, Saratov State University
Ivanov Alexey Nikolaevich, Saratov State Medical University named after V. I. Razumovsky
Abstract: 

Background and Objectives: Here, non-thermal effects induced in the suspension of hollow alginate silver microcontainers after application of short electric field pulses (about 1 ms) of high intensity (about 1 kV/cm) were studied as a prospective tool for remote activation of microcontainers. Alterations in microcontaner’s shells were studied as a function of their composition. Magnetic nanoparticles immobilized within microcontainer’s shells were found to enhance effects that occurred after application of electric field pulses. Alterations found in microcontaner’s shells can be further employed for remote activation of microcontainers and release of encapsulated cargo. Results: The obtained results are the basis for further research of multifunctional microcontainers based on an organic alginate matrix and inorganic metal nanoparticles of silver and magnetite as drug carriers, the permeability, and structure of which can be switched using a non-thermal pulsed electrical action. Conclusion: The proposed microcontainers can be employed as carriers in new effective systems for encapsulation, targeted delivery, and controlled release of various substances in aqueous media responsive towards electric and magnetic fields which are promising in a wide range of biomedical tasks and other applications.

Key words: 
hydrogel
microspheres
magnetite
silver nanoparticles
electric field
Acknowledgments: 
This study was performed within the framework of the State task of the Saratov State Medical University named after V. I. Razumovsky of the Ministry of Health of Russia (project No. 121032500024-2).
Reference: 
  1. Ermakov A. V., Lengert E. V., Venig S. B. Nanomedicine and Drug Delivery Strategies for Theranostics Applications. Izvestiya of Saratov University. Physics, 2020, vol. 20, iss. 2, pp. 116–124. https://doi.org/10.18500/1817- 3020-2020-20-2-116-124
  2. Chatterjee S., Chi-Leung Hui P. Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application. Molecules, 2019, vol. 24, iss. 14, pp. 2547. https://doi.org/10.3390/molecules24142547
  3. Lengert E., Kozlova A., Pavlov A. M., Atkin V., Verkhovskii R., Kamyshinsky R., Demina P., Vasiliev A. L., Venig S. B., Bukreeva T. V. Novel type of hollow hydrogel microspheres with magnetite and silver nanoparticles. Materials Science and Engineering: C, 2019, vol. 98, pp. 1114–1121. https://doi.org/10.1016/j.msec.2019.01.030
  4. Voronin D. V., Sindeeva O. A., Kurochkin M. A., Mayorova O., Fedosov I. V., Semyachkina-Glushkovskaya O., Gorin D. A., Tuchin V. V., Sukhorukov G. B. In Vitro and in Vivo Visualization and Trapping of Fluorescent Magnetic Microcapsules in a Bloodstream. ACS Applied Materials and Interfaces, 2017, vol. 9, iss. 8, pp. 6885–6893. https:// doi.org/10.1021/acsami.6b15811
  5. Markx G. H. The use of electric fields in tissue engineering. Organogenesis, 2008, vol. 4, iss. 1, pp. 11–17. https://doi.org/10.4161/org.5799
  6. Tang T. B., Smith S., Flynn B. W., Stevenson J. T. M., Gundlach A. M., Reekie H. M., Murray A. F., Renshaw D., Dhillon B., Ohtori A., Inoue Y., Terry J. G., Walton A. J. Implementation of wireless power transfer and communications for an implantable ocular drug delivery system. IET Nanobiotechnology, 2008, vol. 2, iss. 3, pp. 72. https://doi.org/10.1049/iet-nbt:20080001
  7. Sutradhar K. B., Sumi C. D. Implantable microchip: the futuristic controlled drug delivery system. Drug Delivery, 2016, vol. 23, iss. 1, pp. 1–11. https://doi.org/10.3109/ 10717544.2014.903579
  8. Ermakov A. V., Lengert E. V., Saveleva M. S., Sukhorukov G. B. Electrically Induced Opening of Composite PLA/SWCNT Microchambers for Implantable Drug Depot Systems. Izvestiya of Saratov University. Physics, 2020, vol. 20, iss. 4, pp. 311–314. https://doi.org/10.18500/1817-3020-2020-20-4-311-314
  9. Caramazza L., Nardoni M., De Angelis A., Paolicelli P., Liberti M., Apollonio F., Petralito S. Proof-of-Concept of Electrical Activation of Liposome Nanocarriers: From Dry to Wet Experiments. Frontiers in Bioengineering and Biotechnology, 2020, vol. 8, pp. 1–14. https://doi.org/10.3389/fbioe.2020.00819
  10. Gulyaev Y. V., Cherepenin V. A., Taranov I. V., Vdovin V. A., Yaroslavov A. A., Kim V. P., Khomutov G. B. Effect of Gold Nanorods on the Remote Decapsulation of Liposomal Capsules Using Ultrashort Electric Pulses. Journal of Communications Technology and Electronics, 2018, vol. 63, iss. 2, pp. 158–162. https://doi.org/10.1134/S106422691802002X
  11. Guo H., Zhao X., Wang J. Synthesis of functional microcapsules containing suspensions responsive to electric fields. Journal of Colloid and Interface Science, 2005, vol. 284, iss. 2, pp. 646–51. https://doi.org/10.1016/j. jcis.2004.10.056
  12. Iahnke A. O. e S., Vargas C. G., Mercali G. D., Rios A. de O., Rahier H., Flôres S. H. Effect of moderate electric field on the properties of gelatin capsule residue-based films. Food Hydrocolloids, 2019, vol. 89, pp. 29–35. https://doi.org/10.1016/j.foodhyd.2018.10.015
  13. Volodkin D. V., Petrov A. I., Prevot M., Sukhorukov G. B. Matrix Polyelectrolyte Microcapsules: New System for Macromolecule Encapsulation. Langmuir, 2004, vol. 20, iss. 8, pp. 3398–3406. https://doi.org/10.1021/la036177z
  14. Lengert E., Yashchenok A. M., Atkin V., Lapanje A., Gorin D. A., Sukhorukov G. B., Parakhonskiy B. V. Hollow silver alginate microspheres for drug delivery and surface enhanced Raman scattering detection. RSC Adv., 2016, vol. 6, iss. 24, pp. 20447–20452. https://doi.org/10.1039/C6RA02019D
  15. Luo W., Hu W., Xiao S. Size Effect on the Thermodynamic Properties of Silver Nanoparticles. The Journal of Physical Chemistry C, 2008, vol. 112, iss. 7, pp. 2359–2369. https://doi.org/10.1021/jp0770155
  16. Angayarkanni S. A., Sunny V., Philip J. Effect of Nanoparticle Size, Morphology and Concentration on Specifi c Heat Capacity and Thermal Conductivity of Nanofluids. Journal of Nanofluids, 2015, vol. 4, iss. 3, pp. 302–309. https://doi.org/10.1166/jon.2015.1167
  17. Rivière L., Lonjon A., Dantras E., Lacabanne C., Olivier P., Gleizes N. R. Silver fillers aspect ratio influence on electrical and thermal conductivity in PEEK/Ag nanocomposites. European Polymer Journal, 2016, vol. 85, pp. 115–125. https://doi.org/10.1016/j.eurpolymj.2016.08.003
Received: 
09.02.2021
Accepted: 
26.04.2021
Published: 
31.08.2021
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