Intrafollicular drug delivery is beneficial in terms of both localized therapy of relevant skin disorders and systemic transportation of bioactive molecules. Vaterite particles are capable of loading and delivering various substances to hair follicles. Possibility to control the duration of their intrafollicular degradation can improve such a particulate delivery system. Here, we propose the use of sonophoresis (1 MHz, 1 W/cm2) to accelerate the resorption of vaterite carriers inside the hair follicles of rats in vivo.
Time- and site-specific release of bioactive compounds mediated by microcontainers immobilized on a surface is of high importance in a variety of tasks related to biomedicine and functional coatings. In the present work, we investigate arrays of hollow microchambers formed by composite shells based on a polylactic acid matrix and single-walled carbon nanotubes filler with high responsiveness towards electric current stimuli. The monitoring of the morphology changes reveals significant damages to the shells of microchambers formed by conductive composite material.
The intensity of upconversion luminescence depends nonlinearly on the excitation intensity. The aim of this work is to study the effect of the temperature of NaYF4:Er,Yb upconversion particles on the dependence of the luminescence intensity on the excitation intensity. The synthesized particles were observed to have the shape of a hexagonal prism with a width of about 440 nm and a height of 445 nm. The upconversion luminescence spectra were obtained in the temperature range of 22–55° C with the excitation intensity in the range of 1.5–9.4 W/cm2.
Magnetic nanoparticles, as controlled drug carriers, provide tremendous opportunities in treating a variety of tumors and brain diseases. In this theoretical study, we used magnetic nanoparticles, such as Superparamagnetic Iron Oxide Nanoparticles (Fe3O4) (SPION). Due to their biocompatibility and stability, these particles represent a unique nanoplatform with a great potential for the development of drug delivery systems. This allows them to be used in medicine for targeted drug delivery, in magnetic resonance imaging and magnetic hyperthermia.
We present results of experimental study of nanoporous Si (SiNР) structure formation by using the method of metal-stimulated chemical etching upon irradiation with small doses of γ-radiation directly in the process of production (in situ). It is shown that the radiation leads to an increase of the crystallization of SiNP structures obtained on previously irradiated substrates. Apparently, this can be explained by a decrease in the initial defectiveness of the silicon substrate due to irradiation with small doses of γ-radiation.
