Izvestiya of Saratov University.
ISSN 1817-3020 (Print)
ISSN 2542-193X (Online)


Краткие сообщения

Sonophoretic acceleration of degradation process for vaterite particles delivered into the hair follicles

Intrafollicular drug delivery is beneficial in terms of both localized therapy of relevant skin disorders and systemic transportation of bioactive molecules. Vaterite particles are capable of loading and delivering various substances to hair follicles. Possibility to control the duration of their intrafollicular degradation can improve such a particulate delivery system. Here, we propose the use of sonophoresis (1 MHz, 1 W/cm2) to accelerate the resorption of vaterite carriers inside the hair follicles of rats in vivo.

Воспоминания об учителе, коллеге и друге Вадиме Семёновиче Анищенко (1943–2020)

30 ноября 2020 г. на 78-м году жизни скоропостижно скончался Вадим Семёнович Анищенко, заведующий кафедрой радиофизики и нелинейной динамики Саратовского национального исследовательского государственного университета имени Н. Г.

Electrically Induced Opening of Composite PLA/SWCNT Microchambers for Implantable Drug Depot Systems

Time- and site-specific release of bioactive compounds mediated by microcontainers immobilized on a surface is of high importance in a variety of tasks related to biomedicine and functional coatings. In the present work, we investigate arrays of hollow microchambers formed by composite shells based on a polylactic acid matrix and single-walled carbon nanotubes filler with high responsiveness towards electric current stimuli. The monitoring of the morphology changes reveals significant damages to the shells of microchambers formed by conductive composite material.

Effect of the Temperature of NaYF4 : Er,Yb Upсonversion Particles on the Formation of Luminescence

The intensity of upconversion luminescence depends nonlinearly on the excitation intensity. The aim of this work is to study the effect of the temperature of NaYF4:Er,Yb upconversion particles on the dependence of the luminescence intensity on the excitation intensity. The synthesized particles were observed to have the shape of a hexagonal prism with a width of about 440 nm and a height of 445 nm. The upconversion luminescence spectra were obtained in the temperature range of 22–55° C with the excitation intensity in the range of 1.5–9.4 W/cm2.

Effect of the temperature of NaYF4:Er,Yb upconversion particles on the formation of luminescence

The intensity of upconversion luminescence depends nonlinearly on the pump power intensity. The study of the dependence under various conditions is important, since it allows us to analyze the changes in the mechanisms of formation of the upconversion luminescence. The aim of this work is to study the effect of the temperature of NaYF4:Er,Yb upconversion particles on the dependence of the luminescence intensity on the intensity of the exciting radiation.

NON-INVASIVE METHODS FOR IN VIVO DETERMINATION OF THE SKIN BARRIER FUNCTION – ADVANTAGES OF CONFOCAL RAMAN MICROSPECTROSCOPY

The physical barrier of the stratum corneum (SC) is provided by corneocytes and the lateral organization of intercellular lipids, which necessarily includes the orthorhombic organization phase. A review of methods used for in vivo non-invasive measurement of skin barrier function has been carried out and it has been shown that all currently used methods are indirect. The most popular method is the measurement of the transepidermal water loss (TEWL), which does not provide information on biophysical parameters responsible for the barrier function of the SC.

Оценка величины обратного кровотока по второй производной пульсовой волны давления

Приведены результаты моделирования формы пульсовой волны давления в двухэлементной модели виндкесселя. Диастолический участок пульсовой волны чаще всего анализировался ранее как результат отражения прямой волны от элементов периферических сосудов. Однако измерения отрицательной линейной скорости кровотока по ультразвуковым допплерограммам однозначно свидетельствуют о наличии обратного кровотока в артериях.

Trapping of Magnetic Nanoparticles in the Blood Stream under the Influence of a Magnetic Field

Magnetic nanoparticles, as controlled drug carriers, provide tremendous opportunities in treating a variety of tumors and brain diseases. In this theoretical study, we used magnetic nanoparticles, such as Superparamagnetic Iron Oxide Nanoparticles (Fe3O4) (SPION). Due to their biocompatibility and stability, these particles represent a unique nanoplatform with a great potential for the development of drug delivery systems. This allows them to be used in medicine for targeted drug delivery, in magnetic resonance imaging and magnetic hyperthermia.

Nanostructured Porous Silicon Layers Formation at Low Doses of γ-Radiation

We present results of experimental study of nanoporous Si (SiNР) structure formation by using the method of metal-stimulated chemical etching upon irradiation with small doses of γ-radiation directly in the process of production (in situ). It is shown that the radiation leads to an increase of the crystallization of SiNP structures obtained on previously irradiated substrates. Apparently, this can be explained by a decrease in the initial defectiveness of the silicon substrate due to irradiation with small doses of γ-radiation.