Izvestiya of Saratov University.

Physics

ISSN 1817-3020 (Print)
ISSN 2542-193X (Online)

For citation:

Svenskaya Y. I., Genina E. A., Tuchin V. V. Sonophoretic acceleration of degradation process for vaterite particles delivered into the hair follicles. Izvestiya of Saratov University. Physics , 2021, vol. 21, iss. 1, pp. 80-85. DOI: 10.18500/1817-3020-2021-21-1-80-85, EDN: HNPFBG

This is an open access article distributed under the terms of Creative Commons Attribution 4.0 International License (CC-BY 4.0).
Published online: 
31.03.2021
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Language: 
English
Heading: 
Brief Communications
Article type: 
Short communication
UDC: 
57.043:53.09
DOI: 
10.18500/1817-3020-2021-21-1-80-85
EDN: 
HNPFBG

Sonophoretic acceleration of degradation process for vaterite particles delivered into the hair follicles

Autors: 
Svenskaya Yulia Igorevna, Saratov State University
Genina Elina Alekseevna, Saratov State University
Tuchin Valery Viсtorovich, Science Medical Center, Saratov State University
Abstract: 

Intrafollicular drug delivery is beneficial in terms of both localized therapy of relevant skin disorders and systemic transportation of bioactive molecules. Vaterite particles are capable of loading and delivering various substances to hair follicles. Possibility to control the duration of their intrafollicular degradation can improve such a particulate delivery system. Here, we propose the use of sonophoresis (1 MHz, 1 W/cm2) to accelerate the resorption of vaterite carriers inside the hair follicles of rats in vivo. The effect of sonication is demonstrated utilizing optical coherence tomography monitoring of the skin and scanning electron microscopy investigation of the plucked hairs. A nine-minute post-treatment of skin in the site of particle delivery allowed us to almost halve the time of their degradation.

Key words: 
transdermal drug delivery
follicular penetration
calcium carbonate carriers
sonophoresis
particulate formulation
resorption
Acknowledgments: 
The authors are grateful to Vsevolod S. Atkin for SEM measurements and Dr. Alla B. Bucharskaya for the help with in vivo experiments.
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Received: 
25.09.2020
Accepted: 
18.11.2020
Published: 
31.03.2021
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