Izvestiya of Saratov University.


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Ерохин П. С., Utkin D. V., Кузнецов О. С., Konnov N. P., Aspen N. A. Application of Atomic Force Microscopy for Detection of Influence of Antibiotic Upon the Microbial Cell (on the Model of E.coli and I Generation Cephalosporins). Izvestiya of Saratov University. Physics , 2013, vol. 13, iss. 2, pp. 28-33. DOI: 10.18500/1817-3020-2013-13-2-28-33

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Application of Atomic Force Microscopy for Detection of Influence of Antibiotic Upon the Microbial Cell (on the Model of E.coli and I Generation Cephalosporins)

Ерохин Павел Сергеевич, Russian Research Anti-Plague Institute «Microbe»
Utkin Denis Valer'evich, Russian Research Anti-Plague Institute «Microbe»
Кузнецов Олег Святославович, Russian Research Anti-Plague Institute «Microbe»
Konnov Nicholas Pavlovich, Russian Research Anti-Plague Institute «Microbe»
Aspen Natalia Aleksandrovna, Russian Research Anti-Plague Institute «Microbe»

Alteration of E.coli cell wall caused by Cefazolin-AKOS was observed atomic force microscopy (AFM). Using semi-contact and contact modes the damaging effect of the Cefazolin-AKOS antibiotic was shown after a 30 minutes exposure. The assessment of physical parameters of cell allow to get more detailed information on the effect of antibiotics on microorganisms.

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