Izvestiya of Saratov University.

Physics

ISSN 1817-3020 (Print)
ISSN 2542-193X (Online)


For citation:

Ерохин П. С., Utkin D. V., Кузнецов О. С., Konnov N. P., Aspen N. A. Application of Atomic Force Microscopy for Detection of Influence of Antibiotic Upon the Microbial Cell (on the Model of E.coli and I Generation Cephalosporins). Izvestiya of Sarat. Univ. Physics. , 2013, vol. 13, iss. 2, pp. 28-33. DOI: 10.18500/1817-3020-2013-13-2-28-33

This is an open access article distributed under the terms of Creative Commons Attribution 4.0 International License (CC-BY 4.0).
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579.23:53.086:615.281

Application of Atomic Force Microscopy for Detection of Influence of Antibiotic Upon the Microbial Cell (on the Model of E.coli and I Generation Cephalosporins)

Autors: 
Ерохин Павел Сергеевич, Russia Research antiplague Institute «MICROBE»
Utkin Denis Valer'evich, Russia Research antiplague Institute «MICROBE»
Кузнецов Олег Святославович, Russia Research antiplague Institute «MICROBE»
Konnov Nicholas Pavlovich, Russia Research antiplague Institute «MICROBE»
Aspen Natalia Aleksandrovna, Russia Research antiplague Institute «MICROBE»
Abstract: 

Alteration of E.coli cell wall caused by Cefazolin-AKOS was observed atomic force microscopy (AFM). Using semi-contact and contact modes the damaging effect of the Cefazolin-AKOS antibiotic was shown after a 30 minutes exposure. The assessment of physical parameters of cell allow to get more detailed information on the effect of antibiotics on microorganisms.

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