Izvestiya of Saratov University.
ISSN 1817-3020 (Print)
ISSN 2542-193X (Online)

semi-contact mode

Application of Atomic Force Microscopy for Detection of Influence of Antibiotic Upon the Microbial Cell (on the Model of E.coli and I Generation Cephalosporins)

Alteration of E.coli cell wall caused by Cefazolin-AKOS was observed atomic force microscopy (AFM). Using semi-contact and contact modes the damaging effect of the Cefazolin-AKOS antibiotic was shown after a 30 minutes exposure. The assessment of physical parameters of cell allow to get more detailed information on the effect of antibiotics on microorganisms.