Izvestiya of Saratov University.


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Koronevskiy N. V., Inozemtseva O. A., Sergeeva B. V., Ushakov A. V., Sergeev S. A. Investigation of the process of recrystallization calcium carbonate microparticles grown on polycaprolactone nanofibers using scanning electron microscopy and X-ray diffraction. Izvestiya of Saratov University. Physics , 2023, vol. 23, iss. 2, pp. 179-187. DOI: 10.18500/1817-3020-2023-23-2-179-187, EDN: ASRADO

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Investigation of the process of recrystallization calcium carbonate microparticles grown on polycaprolactone nanofibers using scanning electron microscopy and X-ray diffraction

Koronevskiy Nikita Vladimirovich, Saratov State University
Inozemtseva Olga Aleksandrovna, Saratov State University
Sergeeva Bela V., Saratov State University
Ushakov Arseni V., Saratov State University
Sergeev Sergey Alekseevich, Saratov State University

Background and Objectives: A method for the mineralization of polycaprolactone nanofibers with microparticles of calcium carbonate (vaterite) is presented. The proposed composite material can be used as a tissue engineering scaffold and a drug delivery vehicle for regenerative medicine. Materials and Methods: The process of recrystallization of vaterite microparticles formed on polycaprolactone fibers into calcite is studied using scanning electron microscopy and X-ray diffraction. Results: The dependences of the mass and quantitative fractions of vaterite/calcite microparticles depending on the duration of the experiment have been compared. Conclusion: The total recrystallization time for vaterite microparticles with an average diameter of 1.2 ± 0.4 microns is 24 hours, and the effective time of their use as a container for targeted drug delivery is limited to 18 hours.

The work was supported by a grant within the innovation project No. 17309ГУ/2022 dated 04 December 2022. The authors express their gratitude to the Laboratory of Diagnostics of Nanomaterials and Structures, as well as to the Center for Collective Use of Saratov State University and personally to Viktor V. Galushka and Maria A. Popova for their assistance in conducting the study.
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