Izvestiya of Saratov University.

Physics

ISSN 1817-3020 (Print)
ISSN 2542-193X (Online)

For citation:

Navolokin N. A., Maslyakova G. N., Bucharskaya A. B., Suleymanova L. V., Kun S. M., Terentyuk G. S., Khlebtsov N. G., Khlebtsov B. N. Dynamics of Morphological and Biochemical Changes in Laboratory Animals with Transplanted Kidney Cancer after Intravenous Injection of Gold Nanoshells. Izvestiya of Saratov University. Physics , 2012, vol. 12, iss. 2, pp. 38-43. DOI: 10.18500/1817-3020-2012-12-2-38-43

This is an open access article distributed under the terms of Creative Commons Attribution 4.0 International License (CC-BY 4.0).
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Language: 
Russian
Heading: 
Physics
UDC: 
57.08:577.29:615: 576.6; 576.33: 616-091.8572:616.716.8(571.5)
DOI: 
10.18500/1817-3020-2012-12-2-38-43

Dynamics of Morphological and Biochemical Changes in Laboratory Animals with Transplanted Kidney Cancer after Intravenous Injection of Gold Nanoshells

Autors: 
Navolokin Nikita Aleksandrovich, Saratov State Medical University named after V. I. Razumovsky
Maslyakova Galina Nikiforovna, Saratov State Medical University named after V. I. Razumovsky
Bucharskaya Alla Borisovna, Saratov State Medical University named after V. I. Razumovsky
Suleymanova Leila Vakhidovna, Saratov State Medical University named after V. I. Razumovsky
Kun Syan Miao, Saratov State Medical University named after V. I. Razumovsky
Terentyuk Georgy Sergeevich, Saratov State Medical University named after V. I. Razumovsky
Khlebtsov Nikolay Grigor'evich, Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences (IBPPM RAS)
Khlebtsov Boris Nikolaevich, Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences (IBPPM RAS)
Abstract: 

The effect of intravenously injected nanoshells on white outbred male rats with transplanted tumor of kidney cancer was studied. The blood biochemical parameters and morphological changes in the rat internal organs were examined during 24 h after nanoparticle injection. The most pronounced changes were observed 45 min – 2 h after nanoparticle injection and were reversible.

Key words: 
nanoparticles
gold nanoshells
toxicity
morphology
biochemistry
transplanted cancer
kidney cancer
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