Izvestiya of Saratov University.

Physics

ISSN 1817-3020 (Print)
ISSN 2542-193X (Online)

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Plastun I. L., Bryksin K. A., Mayorova O. A., Babkov L. M. Spectral manifestations of hyaluronic acid intermolecular interaction with nitrogen-containing amino acids. Izvestiya of Saratov University. Physics , 2024, vol. 24, iss. 2, pp. 126-137. DOI: 10.18500/1817-3020-2024-24-2-126-137, EDN: DRKPRT

This is an open access article distributed under the terms of Creative Commons Attribution 4.0 International License (CC-BY 4.0).
Published online: 
28.06.2024
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Language: 
Russian
Heading: 
Optics and spectroscopy. Laser physics
Article type: 
Article
UDC: 
539.194:539.196.3:544.174.3
DOI: 
10.18500/1817-3020-2024-24-2-126-137
EDN: 
DRKPRT

Spectral manifestations of hyaluronic acid intermolecular interaction with nitrogen-containing amino acids

Autors: 
Plastun Inna L'vovna, Yuri Gagarin State Technical University of Saratov
Bryksin Kirill A., Yuri Gagarin State Technical University of Saratov
Mayorova Oksana Aleksandrovna, Saratov State University
Babkov Lev Mikhailovich, Saratov State University
Abstract: 

Background and Objectives: Manifestations of intermolecular interaction based on hydrogen bonding in hyaluronic acid IR spectra and in multicomponent mixtures of hyaluronic acid with nitrogen-containing amino acids, which are part of mucin of the mucous membrane of the bladder and protein carrier microgels, have been studied using experimental and theoretical IR spectroscopy. Materials and Methods: Comparison of measured and calculated hyaluronic acid IR spectra in harmonic approximation is performed. Calculations of molecular complexes structure and their corresponding IR spectra were carried out, followed by an analysis of the parameters of the hydrogen bonds formed. Results: Estimates of hyaluronic acid complexation with amino acids strength, which are part of protein microgels used in targeted therapy, and in target cells proteins were given. Conclusion: It has been found that the presence of an additional protein structure significantly increases the hyaluronic acid interaction with mucous membrane mucin protein due to intermolecular complexation based on polar basic amino acids.

Key words: 
hyaluronic acid
IR spectrum
experimental measurements
molecular modeling
amino acids
density functional theory
hydrogen bonds
Acknowledgments: 
The research was supported by the Russian Science Foundation (project No. 21-75-10042, https://rscf.ru/project/21-75-10042/).
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Received: 
18.02.2024
Accepted: 
15.04.2024
Published: 
28.06.2024
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