Izvestiya of Saratov University.


ISSN 1817-3020 (Print)
ISSN 2542-193X (Online)

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Bucharskaya A. B., Genina E. A., Bashkatov A. N., Terentyuk G. S., Navolokin N. A., Maslyakova G. N., Khlebtsov N. G., Khlebtsov B. N., Tuchin V. V. Morphological Changes in Transplanted Sarcoma S45 at Photodynamic Therapy Using Nanocomposites Based on Gold Nanorods. Izvestiya of Saratov University. Physics , 2015, vol. 15, iss. 4, pp. 22-27. DOI: 10.18500/1817-3020-2015-15-4-22-27

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УДК 616-006.04; 616-018; 535.361; 53.06

Morphological Changes in Transplanted Sarcoma S45 at Photodynamic Therapy Using Nanocomposites Based on Gold Nanorods

Bucharskaya Alla Borisovna, Saratov State Medical University named after V. I. Razumovsky
Genina Elina Alekseevna, Saratov State University
Bashkatov Alexey Nikolaevich, Saratov State University
Terentyuk Georgy Sergeevich, Saratov State Medical University named after V. I. Razumovsky
Navolokin Nikita Aleksandrovich, Saratov State Medical University named after V. I. Razumovsky
Maslyakova Galina Nikiforovna, Saratov State Medical University named after V. I. Razumovsky
Khlebtsov Nikolay Grigor'evich, Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences (IBPPM RAS)
Khlebtsov Boris Nikolaevich, Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences (IBPPM RAS)
Tuchin Valery Viсtorovich, Science Medical Center, Saratov State University

Photodynamic therapy (PDT) of cancer is an advanced application of gold nanostructures. The purpose of the research is to study the morphological changes in the transplanted sarcoma S45 at PDT using nanocomposites based on gold nanorods (GNRs). GNRs synthesized with the germ method and covered by a silicon coating, functionalized by hematoporphyrin, were intratumorally injected in rats with transplanted sarcoma S45. The tumor was irradiated by He-Ne laser with a wavelength of 632.8 nm. A day later, the animals were withdrawn from the experiment, and the tumor tissue was sampled for morphological studies. After PDT, expressed necrobiotic changes on the background of the inflammatory reaction were observed in transplanted tumors.

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