For citation:
Bucharskaya A. B., Terentyuk G. S., Maslyakova G. N., Matveeva O. V., Navolokin N. A., Dicht N. I., Khlebtsov N. G., Khlebtsov B. N. Morphological Changes in the Internal Organs and Implanted Liver Tumor after Intravenous Injection of Gold Nanorods in Rats with Diabetes and Transplanted Tumor. Izvestiya of Saratov University. Physics , 2012, vol. 12, iss. 2, pp. 31-37. DOI: 10.18500/1817-3020-2012-12-2-31-37
Morphological Changes in the Internal Organs and Implanted Liver Tumor after Intravenous Injection of Gold Nanorods in Rats with Diabetes and Transplanted Tumor
The effects of gold nanorods on the internal organs and the transplanted liver tumor were studied in rats with simulated alloxan diabetes and transplanted liver tumors after intravenous administration. Assessed morphofunctional changes and biodistribution of gold in the internal organs and transplanted liver tumor. The study found that a single intravenous injection of gold nanorods does not cause significant morphological changes in the internal organs and transplanted tumors in rats with alloxan diabetes and transplanted tumor. There was a significant accumulation of gold in the spleen and liver of animals in all experimental groups.
- Wideroff L., Gridley G., Chow W.-H., Linet M. Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark // J. Natl. Cancer Inst. 1997. Vol. 89. P. 1360–1365.
- Lagiou P., Kuper H., Stuver S. O., Tzonou A., Trichopoulos D., Adami H.-O. Role of diabetes mellitus in the etiology of hepatocellular carcinoma // J. Natl. Cancer Inst. 2000. Vol. 92. P. 1096–1099.
- Michels K. B., Solomon C. G., Hu F. B. Type 2 diabetes and subsequent incidence of breast cancer in the Nurses’ Health Study // Diabetes Care. 2003. Vol. 26. P. 1752–1758.
- Weiderpass E., Ye W., Vainio H., Kaaks R., Adami H.-O. Reduced risk of prostate cancer among patients with diabetes mellitus // Intern. J. Cancer. 2002. Vol. 102. P. 258–261.
- Goranson E. S., Botham F., Willms M. Inhibition of Growth of Transplanted Hepatomas in Alloxanized Wistar Rats // Cancer Res. 1954. Vol. 14. P. 730–733
- Garvie W. H. H. The influence of alloxan diabetes on experimental cancer // Br. J. Surg. 1968. Vol. 22. P. 128–132.
- Guo R., Song Y., Wang G., Murray R. W. Does core size matter in the kinetics of ligand exchanges of monolayerprotected Au clusters? // J. Amer. Chem. Soc. 2005. Vol. 127. P. 2752–2757.
- Connor E. E., Mwamuka J., Gole A., Murphy C. J., Wyatt M. D. Gold nanoparticles are aken up by human cells but do not cause acute cytotoxicity // Small. 2005. Vol. 1. P. 325–327.
- BarathManiKanth S., Kalishwaralal K., Sriram M., Ram Kumar Pandian S. Antioxidant effect of gold nanoparticles restrains hyperglycemic conditions in diabetic mice // J. Nanobiotechnology. 2010. 8:16. DOI: https://doi.org/10.1186/1477-3155-8-16. 10. Lenzen S. The mechanisms of alloxan and streptozotocin diabetes // Diabetologia. 2008. Vol. 51. P. 216–226.
- 1295 reads