Izvestiya of Saratov University.

Physics

ISSN 1817-3020 (Print)
ISSN 2542-193X (Online)


For citation:

Bucharskaya A. B., Terentyuk G. S., Maslyakova G. N., Matveeva O. V., Navolokin N. A., Dicht N. I., Khlebtsov N. G., Khlebtsov B. N. Morphological Changes in the Internal Organs and Implanted Liver Tumor after Intravenous Injection of Gold Nanorods in Rats with Diabetes and Transplanted Tumor. Izvestiya of Sarat. Univ. Physics. , 2012, vol. 12, iss. 2, pp. 31-37. DOI: 10.18500/1817-3020-2012-12-2-31-37

This is an open access article distributed under the terms of Creative Commons Attribution 4.0 International License (CC-BY 4.0).
Full text:
(downloads: 70)
Language: 
Russian
Heading: 
UDC: 
616.379-008.64:57.08:577.29:615: 576.6; 576.33: 616-091.8572:616.716.8(571.5)

Morphological Changes in the Internal Organs and Implanted Liver Tumor after Intravenous Injection of Gold Nanorods in Rats with Diabetes and Transplanted Tumor

Autors: 
Bucharskaya Alla Borisovna, Saratov State Medical University named after V. I. Razumovsky
Terentyuk Georgy Sergeevich, Saratov State Medical University named after V. I. Razumovsky
Maslyakova Galina Nikiforovna, Saratov State Medical University named after V. I. Razumovsky
Matveeva Olga Viktorovna, Saratov State University
Navolokin Nikita Aleksandrovich, Saratov State Medical University named after V. I. Razumovsky
Dicht Natalia Ivanovna, Saratov State Medical University named after V. I. Razumovsky
Khlebtsov Nikolay Grigor'evich, Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences (IBPPM RAS)
Khlebtsov Boris Nikolaevich, Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences (IBPPM RAS)
Abstract: 

The effects of gold nanorods on the internal organs and the transplanted liver tumor were studied in rats with simulated alloxan diabetes and transplanted liver tumors after intravenous administration. Assessed morphofunctional changes and biodistribution of gold in the internal organs and transplanted liver tumor. The study found that a single intravenous injection of gold nanorods does not cause significant morphological changes in the internal organs and transplanted tumors in rats with alloxan diabetes and transplanted tumor. There was a significant accumulation of gold in the spleen and liver of animals in all experimental groups.

Reference: 
  1. Wideroff L., Gridley G., Chow W.-H., Linet M. Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark // J. Natl. Cancer Inst. 1997. Vol. 89. P. 1360–1365.
  2. Lagiou P., Kuper H., Stuver S. O., Tzonou A., Trichopoulos D., Adami H.-O. Role of diabetes mellitus in the etiology of hepatocellular carcinoma // J. Natl. Cancer Inst. 2000. Vol. 92. P. 1096–1099.
  3. Michels K. B., Solomon C. G., Hu F. B. Type 2 diabetes and subsequent incidence of breast cancer in the Nurses’ Health Study // Diabetes Care. 2003. Vol. 26. P. 1752–1758.
  4. Weiderpass E., Ye W., Vainio H., Kaaks R., Adami H.-O. Reduced risk of prostate cancer among patients with diabetes mellitus // Intern. J. Cancer. 2002. Vol. 102. P. 258–261.
  5. Goranson E. S., Botham F., Willms M. Inhibition of Growth of Transplanted Hepatomas in Alloxanized Wistar Rats // Cancer Res. 1954. Vol. 14. P. 730–733
  6. Garvie W. H. H. The influence of alloxan diabetes on experimental cancer // Br. J. Surg. 1968. Vol. 22. P. 128–132.
  7. Guo R., Song Y., Wang G., Murray R. W. Does core size matter in the kinetics of ligand exchanges of monolayerprotected Au clusters? // J. Amer. Chem. Soc. 2005. Vol. 127. P. 2752–2757.
  8. Connor E. E., Mwamuka J., Gole A., Murphy C. J., Wyatt M. D. Gold nanoparticles are aken up by human cells but do not cause acute cytotoxicity // Small. 2005. Vol. 1. P. 325–327.
  9. BarathManiKanth S., Kalishwaralal K., Sriram M., Ram Kumar Pandian S. Antioxidant effect of gold nanoparticles restrains hyperglycemic conditions in diabetic mice // J. Nanobiotechnology. 2010. 8:16. DOI: https://doi.org/10.1186/1477-3155-8-16. 10. Lenzen S. The mechanisms of alloxan and streptozotocin diabetes // Diabetologia. 2008. Vol. 51. P. 216–226.