Izvestiya of Saratov University.

Physics

ISSN 1817-3020 (Print)
ISSN 2542-193X (Online)

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Verkhovskii R. A., Anisimov R. A., Lomova M. V., Tuchina D. K., Lazareva E. N., Doronkina A. A., Mylnikov A. M., Navolokin N. A., Kochubey V. I., Yanina I. I. Cytotoxicity of various types of coated upconversion nanoparticles. Overview. Izvestiya of Saratov University. Physics , 2022, vol. 22, iss. 4, pp. 357-373. DOI: 10.18500/1817-3020-2022-22-4-357-373, EDN: DLYOKR

This is an open access article distributed under the terms of Creative Commons Attribution 4.0 International License (CC-BY 4.0).
Published online: 
30.11.2022
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Russian
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Nanotechnologies, nanomaterials and metamaterials
Article type: 
Article
UDC: 
53.06:615.4:615.9:576.5
DOI: 
10.18500/1817-3020-2022-22-4-357-373
EDN: 
DLYOKR

Cytotoxicity of various types of coated upconversion nanoparticles. Overview

Autors: 
Verkhovskii Roman A., Saratov State University
Anisimov Roman A., Saratov State University
Lomova Maria V., Saratov State University
Tuchina Daria K., Saratov State University
Lazareva Ekaterina Nikolaevna, Saratov State University
Doronkina Anna A., Saratov State University
Mylnikov Artyom M., Saratov State Medical University named after V. I. Razumovsky
Navolokin Nikita Aleksandrovich, Saratov State Medical University named after V. I. Razumovsky
Kochubey Vyacheslav Ivanovich, Saratov State University
Yanina Irina Iur'evna, Saratov State University
Abstract: 

Background and Objectives: The object of the study was the cytotoxicity of various types of coated upconversion nanoparticles. The aim is to overview the literature on the cytotoxicity of various types of upconversion nanoparticles without/with coating and to search for their maximum permissible concentration when applied to cell. Materials and Methods: The approach used has been the analysis of recent publications on the topic. Results: Upconversion nanoparticles are promising for fluorescence imaging and cancer therapy. Nanoparticles with additional shells or functionalized by surface coating with targeted or photoactive molecules are considered. The toxicological effect of nanoparticles on living organisms is of decisive importance when they are used in therapy or diagnostics. The “dark” cytotoxicity of particles is considered. The cytotoxicity of particles depends on the total number of nanoparticles that have penetrated into the cell. Conclusion: Based on the analysis of a large number of publications, it can be concluded that nanoparticles coated with silicon dioxide (SiO2) are characterized by the least cytotoxic effect, which opens up prospects for the use of this type of nanoparticles in medical practice. 

Key words: 
cytotoxicity
upconversion particles
shell
concentration
dose
Acknowledgments: 
The study was supported by a grant Russian Science Foundation No. 21-72-10057, https://rscf.ru/project/21-72-10057/.
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Received: 
04.04.2022
Accepted: 
23.05.2022
Published: 
30.11.2022
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