Izvestiya of Saratov University.


ISSN 1817-3020 (Print)
ISSN 2542-193X (Online)

For citation:

Severyukhina A. N., Svenskaya Y. I., Gorin D. A. Composite Nonwoven Materials with Microparticles for Regenerative Surgery. Izvestiya of Sarat. Univ. Physics. , 2013, vol. 13, iss. 2, pp. 67-69. DOI: 10.18500/1817-3020-2013-13-2-67-69

This is an open access article distributed under the terms of Creative Commons Attribution 4.0 International License (CC-BY 4.0).
Full text:
(downloads: 53)
677.4; 617-089.844

Composite Nonwoven Materials with Microparticles for Regenerative Surgery

Severyukhina Alexandra Nikolaevna, Saratov State University
Svenskaya Yulia Igorevna, Saratov State University
Gorin Dmitry Aleksandrovich, Saratov State University

Composite nonwoven materials with different medical supplements are widely used for regenerative surgery. Majority of these medicines are cytotoxic, therefore precise drug delivery is necessary to decrease toxic effects. We propose novel polymer nanofibrous material impregnated by core–shell microstructures that can provide targeted and controllable release of encapsulated drugs. This biodegradable scaffold system was fabricated using mixing of calcium carbonate microparticles with chitosan solutions followed by electrospinning method.

  1. Huang Z.-M., Zhang Y.-Z., Kotaki M., Ramakrishna S. A review on polymer nanofi bers by electrospinning and their applications in nanocomposites // Composites Science and Technology. 2003. Vol. 63. P. 2223–2253
  2. Ondarcuhu T., Joachim C. Drawing a single nanofibre over hundreds of microns // Europhys Lett. 1998. Vol. 42, № 2. P. 215–220.
  3. Feng L., Li S., Li H., Zhai J., Song Y., Jiang L., Zhu D. Super-Hydrophobic Surface of Aligned Polyacrylonitrile Nanofibers // Angew Chem. Intern. Ed. Engl. 2002. Vol. 41, № 7. P. 1221–1223.
  4. Martin C. R. Membrane-based synthesis of nanomaterials // Chem. Mater. 1996. Vol. 8. P. 1739–1746.
  5. Ma P. X., Zhang R. Synthetic nano-scale fi brous extracellular matrix // J. Biomed Mat. Res. 1999. Vol. 46. P. 60–72.
  6. Liu G. J., Ding J. F., Qiao L. J., Guo A., Dymov B. P., Gleeson J. T., Hashimoto T., Saijo K. Polystyrene-block-poly (2-cinnamoylethyl methacrylate) nanofi bers-Preparation, characterization, and liquid crystalline properties // Chem-A European J. 1999. Vol. 5. P. 2740–2749.
  7. Bognitzki M., Czado W., Frese T., Schaper A., Hellwig M., Steinhart M., Greiner A., Wendorff J. H. Nanostructured Fibers via Electrospinning // Advanced Materials. 2001. Vol. 13, № 1. P. 70–72.
  8. Deitzel J. M., Kleinmeyer J., Hirvonen J. K. Controlled deposition of electrospun poly(ethylene oxide) fi bers // Polymer. 2001. Vol. 42. P. 8163–8170.
  9. Fong H., Reneker D. H. Electrospinning and formation of nanofi bers // Structure formation in polymeric fi bers / ed. D. R. Salem. Munich : Hanser, 2001. P. 225–246.
  10. Reneker D. H., Yarin A. L. Electrospinning jets and polymer nanofi bers // Polymer. 2008. Vol. 49. P. 2387–2425.
  11. Svenskaya Yu. I. Nanoparticles, nanostructured coatings and microcontainers : technology, properties, applications // Proc. of III Intern. Workshop. Saratov, 2011.
  12. Volodkin D. V., Petrov A. I., Prevot M., Sukhorukov G. B. Matrix polyelectrolyte microcapsules : New system for macromolecule encapsulation // Langmuir. 2004. Vol. 20. P. 3398–3406.