Izvestiya of Saratov University.
ISSN 1817-3020 (Print)
ISSN 2542-193X (Online)


Биофизика и медицинская физика

Application of Thermal Imaging Diagnostics in Assessment of Inflammatory Response after Sclerotherapy in Patients with Lower Limb Varicose Disease

Background and Objectives: Sclerotherapy of the lower extremities veins refers to one of the promising methods of treating patients with varicose veins. However, at present, there are no effective methods for assessing the condition of sclerotic veins during sclerotherapy.

Study of Ethanol Impact on the Transepidermal Transport of Indocyanine Green with Backscattering Spectroscopy

In the work, impact of aqueous 40%-ethanol solution on the transepidermal transport of photodynamic dye indocyanine green has been studied with backscattering spectroscopy. It has been first obtained the value of the dye diffusion coefficient through the stratum corneum ex vivo at the use of ethanol as a diffusion enhancer: (6.85±3.75)×10−7 cm2/s.

Processing and Visualization of Large Data Arrays in Taxonomic and Evolutionary Studies of Living Nature1 (a review)

A review is given of recent advances in the taxonomic study of organisms and current views on biological evolution and the origin of life. The steady increase in bioinformation resources is noted, which reflects the results of studies of the Earth’s biodiversity with the use of deciphered structures of biomacromolecules (DNA, RNA, proteins, etc.). This necessitates accounting for the specific character of manipulations with large data arrays, which is currently termed the big data problem.

Investigation of Mildronat ® Diffusion in Human Eye Sclera

Background and Objectives: Diseases of retina and optic nerve are the major causes of vision loss. The use of new drugs in the treatment of these diseases can reduce the decline of visual function due to the involvement of additional mechanisms of cell metabolism compensation. Thus, investigation of the drug diffusion in sclera is an important task at estimation of dose necessary for achievement of enough drug concentration in internal eye tissues.

Influence of the Hydrogen Bond on the IR-spectrum and Structure of Molecular Complex of Diamond Nanoparticles and DNA Bases

Background and Objectives: Using molecular modeling by the density functional theory method we analyze a hydrogen bonds formation and their influence on IR-spectrum and structure of molecular complex which is formed as the interaction of complementary couple of DNA nucleobases adenine and timin and nanodiamonds surrounded with carboxylic groups. As an example of nanodiamonds adamantine has been used. Intermolecular forces and structure of hydrogen bonds are investigated.

Investigation of Delay Time in Interaction between the Regulatory Circuits in the Cardiovascular System of Healthy Humans Using Modeling of Phase Dynamics

Background and Objectives: Low-frequency oscillations with a basic frequency of about 0.1 Hz are observed in the human heart rate and peripheral microcirculation. It is found out that these processes are self-oscillatory and interact between themselves. However, the details and characteristics of this interaction including the direction of coupling and delays in coupling functions are not well studied yet.

Applying Methods of Diffuse Light Scattering and Optical Trapping for Assessing Blood Rheological Parameters: Erythrocytes Aggregation in Diabetes Mellitus

Background and Objectives: Aggregation parameters of blood characterize red blood cells interaction processes which play a major role in the microcirculation regulation. It was shown that these parameters are significantly different in case of Diabetes Mellitus (DM) and therefore can be proposed as a novel parameter of the disease state and therapy efficiency.

Optical Clearing of Cranial Bone by Multicomponent Immersion Solutions and Cerebral Venous Blood Flow Visualization

Background and Objectives: Optical clearing of bone tissue is of great practical interest, which opens up the possibility of the development of minimally invasive laser diagnostics and brain therapy. The aim of this work is the study of the optical clearing of cranial bone using multicomponent optical clearing agents, and the possibility of the measurement of cerebral blood flow.

Optical Study of Blood Rheological Properties for Krushinsky – Molodkina Strain Rats with Diabetes Mellitus and Acute Disturbances of the Cerebral Circulation

Background and Objectives: The aim of the study was to assess the hemorheological parameters for rats with experimental diabetes and acute disturbances of the cerebral circulation. Materials and Methods: For modeling of the acute cerebral circulation disturbances (ACCD) the epilepsy-prone rats of Krushinsky–Molodkina strain were used. During the application of the specifically elaborated standard procedure of sound stimulation a strong sound impact leads to ACCD predominantly of the hemorrhagic type.

Improved Data Processing Algorithm for Laser Ektacytometry of Red Blood Cells

Background and Objectives: Red blood cells deliver oxygen to organs and tissues. In case of tropical malaria, blood anemia, diabetes mellitus and many other diseases, the cells become corrupted. These pathologies lead in altering deformability of the cells, i.e ability to change their shape under external forces. Precise measurement of cell’s deformability gives important medical information which helps to cure and monitor the most wide spread diseases more effectively.

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