Izvestiya of Saratov University.
ISSN 1817-3020 (Print)
ISSN 2542-193X (Online)


Биофизика и медицинская физика

Estimation of the Value of Reverse Blood Flow in the Artery by the Second Derivative of the Pulse Pressure Wave

Background and Objectives: Previously, the diastolic section of the pulse wave was most often analyzed as the result of reflection of a direct wave from the elements of peripheral vessels. However, measurements of the negative linear velocity of blood flow using ultrasound dopplerograms clearly indicate the presence of reverse blood flow in the arteries. The aim of the work was to establish the relationship of the second derivative of the pulse pressure wave with the value of the reverse blood flow in the arterial bed.

Non-invasive Methods for in vivo Determination of the Skin Barrier Function – Advantages of Confocal Raman Microspectroscopy

The physical barrier of the stratum corneum (SC) is provided by corneocytes and the lateral organization of intercellular lipids, which necessarily includes the orthorhombic organization phase. A review of methods used for in vivo non-invasive measurement of skin barrier function has been carried out and it has been shown that all currently used methods are indirect. The most popular method is the measurement of the transepidermal water loss (TEWL), which does not provide information on biophysical parameters responsible for the barrier function of the SC.

Distal Pulse Measurement Provides Statistical, but not Dynamical, Features of the Central Pulse

Heart rate variability is recognized in medicine as an important prognostic factor. It is generally believed that the temporal characteristics of the pulse signal do not depend on the measurement point. Specifically, the distal (on the fingers) arrangement of the photoplethysmographic sensors. Using a high-precision measurement technique, we show that on the way from the heart to distally located measurement points, the value of each individual beat-to-beat time may change.

Reflection Index of the Pulse Wave for Young Athletes

Background and Objectives: The cardiovascular system of young athletes is subject to functional changes associated with an increase in both vasodilator capacity of blood vessels and an increase in vasoconstriction. Diagnostics of functional changes in the vascular system of athletes can be carried out by the sphygmographic method when measuring the reflection index, which characterizes the change in the tone of the smooth muscle wall of the vessel during an occlusive test.

Nanomedicine and Drug Delivery Strategies for Theranostics Applications

Background and Objectives: Nanomedicine and drug delivery systems are a relatively new but rapidly developing branch of science, which investigate materials in the nano- and microscale range as diagnostic tools or carrier for delivery of therapeutic agents to specific targets within the body in a controlled manner. As far as the systemic administration faces a range of problems that cannot be solved by traditional approaches, it becomes extremely relevant to develop novel therapeutic options.

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