Izvestiya of Saratov University.

Physics

ISSN 1817-3020 (Print)
ISSN 2542-193X (Online)


For citation:

Firsova S. S., Bucharskaya A. B., Maslyakova G. N., Zlobina O. V., Matveeva O. V., Bugaeva I. O., Khlebtsov N. G., Khlebtsov B. N., Bogatyrev V. A. The Changes of Morphological Indicators of Bone Marrow and Peripheral Blood at Long Exposure of Gold Nanoparticles. Izvestiya of Sarat. Univ. Physics. , 2011, vol. 11, iss. 2, pp. 54-57. DOI: 10.18500/1817-3020-2011-11-2-54-57

This is an open access article distributed under the terms of Creative Commons Attribution 4.0 International License (CC-BY 4.0).
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576.6:576.33:615.017:616.079:615.2/.3.001.37:616091.8

The Changes of Morphological Indicators of Bone Marrow and Peripheral Blood at Long Exposure of Gold Nanoparticles

Autors: 
Firsova Svetlana Sergeevna, Saratov State Medical University named after V. I. Razumovsky
Bucharskaya Alla Borisovna, Saratov State Medical University named after V. I. Razumovsky
Maslyakova Galina Nikiforovna, Saratov State Medical University named after V. I. Razumovsky
Zlobina Olga Vjacheslavovna, Saratov State Medical University named after V. I. Razumovsky
Matveeva Olga Viktorovna, Saratov State University
Bugaeva Irina Olegovna, Saratov State Medical University named after V. I. Razumovsky
Khlebtsov Nikolay Grigor'evich, Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences (IBPPM RAS)
Khlebtsov Boris Nikolaevich, Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences (IBPPM RAS)
Bogatyrev Vladimir Aleksandrovich, Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences (IBPPM RAS)
Abstract: 

The exposure of gold nanoparticles with different size on the morphological indicators of red bone marrow and peripheral blood of white not purebred rats at long peroral introduction were studied in experiment. The mutagen influence of gold nanoparticles on polychromatophilous erythrocytes of bone marrow were estimated by micronuclear test. During research the reduction of quantity of leukocytes in peripheral blood and the erythrocyte volume reduction with increase of their hemoglobin saturation were revealed. The changes reflecting the mutagen activity of gold nanoparticles were not revealed at carrying out micronuclear test. The changes of morphological indicators of bone marrow testify about stimulation processes occurring in a marrow lymphocytic and myelocytic sprouts of hemopoiesis as a result of reduction of mature cells in peripheral blood.

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