Izvestiya of Saratov University.

Physics

ISSN 1817-3020 (Print)
ISSN 2542-193X (Online)


For citation:

Postnov D. D., Sosnovtseva O. V., Postnov D. E. TGF-Mode Elimination in Hemodynamics of Vascular Nephron Tree. Izvestiya of Saratov University. Physics , 2011, vol. 11, iss. 2, pp. 66-71. DOI: 10.18500/1817-3020-2011-11-2-66-71

This is an open access article distributed under the terms of Creative Commons Attribution 4.0 International License (CC-BY 4.0).
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Russian
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UDC: 
577.31

TGF-Mode Elimination in Hemodynamics of Vascular Nephron Tree

Autors: 
Postnov Dmitrij Dmitrievich, Saratov State University
Sosnovtseva Olga Valentinovna, The University of Copenhagen
Postnov Dmitry Engelevich, Saratov State University
Abstract: 

By means of numerical experiment, we studied the oscillating patterns, generated by the interaction of nephrons in the vascular tree and compared them with experimental data. Based on these results we calculated the blood flow in all branches, as well as its Fourier power spectra, to characterize its spectral composition. We reveal the mechanism responsible for the effective localization of hemodynamic interaction based on elimination of modulation rhythms of blood flow at each branching level.

Reference: 
  1. Leyssac P. P., Baumbach L. An oscillating intratubular pressure response to alterations in the loop of Henle fl ow in the rat kidney // Acta Physiol. Scand. 1983. Vol. 117, № 3. P. 415–419.
  2. Holstein-Rathlou N. -H., Leyssac P. P. TGF-mediated oscillations in the proximal intratubular pressure: differences between spontaneously hypertensive rats and Wistar-Kyoto rats // Acta Physiol. Scand. 1986. Vol. 126, № 3. Р. 333–339.
  3. Leyssac P. P., Holstein-Rathlou N. -H. Tubulo-glomerular feedback response: enhancement in adult spontaneously hypertensive rats and effect of anaesthetics // Pfl ugers. Arch. 1989. Vol. 413, № 3. Р. 267–272.
  4. Kallskog O., Marsh D. J. TGF-initiated vascular interactions between adjacent nephrons in the rat kidney // Amеr J. Physiol. Renal Physiol. 1990. Vol. 259, № 1. P. F60–F64.
  5. Holstein-Rathlou N.-H. Synchronization of proximal intratubular pressure oscillations: evidence for interaction between nephrons // Pfl ugers Archiv. 1987. Vol. 408, № 5. P. 438–439.
  6. Laugesen J. L., Sosnovtseva O. V., Mosekilde E., HolsteinRathlou N.-H., Marsh D. J. Coupling-induced complexity in nephron models of renal blood fl ow regulation // Amer. J. Physiol. Regul. Integr. Comp. Physiol. 2010. Vol. 298, № 4. Р. R997–R1006.
  7. Postnov D. E., Sosnovtseva O. V., Mosekilde E., HolsteinRathlou N.-H. Cooperative phase dynamics in coupled nephrons // Intern. J. of Modern Physics. 2001. Vol. 15, № 23. P. 3079–3098.
  8. Sosnovtseva O. V., Pavlov A. N., Mosekilde E., Holstein-Rathlou N. -H. Bimodal oscillations in nephron autoregulation // Physical Review. 2002. Vol. 66, № 6. Р. 061909-1–061909-7.
  9. Holstein-Rathlou N. -H., Sosnovtseva O. V., Pavlov A. N., Cupples W. A., Sorensen C. M., Marsh D. J. Nephron blood fl ow dynamics measured by laser speckle contrast imaging // Amer. J. Physiol. Renal Physiol. 2011. Vol. 300, № 2. Р. F319–F329.
  10. Barfred M., Mosekilde E., Holstein-Rathlou N.-H. Bifurcation analysis of nephron pressure and fl ow regulation // CHAOS. 1996. Vol. 6, № 3. P. 280–287.
  11. Marsh D. J., Sosnovtseva O. V., Mosekilde E., HolsteinRathlou N.-H. Vascular coupling induces synchronization, quasiperiodicity,and chaos in a nephron tree // CHAOS. 2007. Vol. 17, № 1. P. 015114.
  12. Wagner A. J., Holstein-Rathlou N.-H., Marsh D. J. Internephron coupling by conducted vasomotor responses in normotensive and spontaneously hypertensive rats // Amer. J. Physiol. Renal Physiol. 1997. Vol 272, № 3. P. F372–F379.
  13. Holstein-Rathlou N.-H., Yip K.-P., Sosnovtseva O. V., Mosekilde E. Synchronizaton phenomena in nephronnephron interaction // CHAOS. 2001. Vol. 11, № 2. Р. 417–426.