Для цитирования:
Сагайдачная Е. А., Янина И. Ю., Кочубей В. И. Перспективы применения апконверсионных частиц NaYF4:Er,Yb для фототерапии // Известия Саратовского университета. Новая серия. Серия: Физика. 2018. Т. 18, вып. 4. С. 253-274. DOI: 10.18500/1817-3020-2018-18-4-253-274
Перспективы применения апконверсионных частиц NaYF4:Er,Yb для фототерапии
В работе описан принцип действия функционализированных апконверсионных частиц, позволяющих проводить фотодинамическую и фототермическую терапии опухоли с одновременным контролем температуры и возможностью визуализировать область терапии. Апконверсионные частицы являются перспективным материалом для комплексной фототерапии с одновременным контролем нагрева биоткани, поскольку могут позволить увеличить глубину терапевтического воздействия за счет большой глубины проникновения необходимого возбуждающего излучения. Рассмотрены особенности гидротермального метода синтеза апконверсионных частиц NaYF4:Er,Yb, представляющегося наиболее перспективным. Гидротермальный метод позволяет варьировать параметры синтезируемых частиц путем регулировки температуры и времени синтеза, концентрации пассивирующего и фторирующего агентов. При этом могут быть получены частицы различной морфологии от стержней до пластинок различных размеров (10 нм – 5 мкм). Последующая функционализация частиц фотосенсибилизатором обеспечивает фотодинамическое действие. Приведен обзор результатов исследований in vitro на маркерных веществах и клетках, подтверждающих эффективность генерации токсических форм кислорода в присутствии функционализированных апконверсионных частиц и их цитотоксического действия. Показано, что использование таких частиц позволяет увеличить глубину действия терапии согласно исследованиям in vivo на мышах, а значит, увеличить ее эффективность и расширить границы применимости. Описанные процессы могут дать основания для развития методов фотодинамической терапии, направленных на расширение области применения и функциональных возможностей терапии.
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