Izvestiya of Saratov University.

Physics

ISSN 1817-3020 (Print)
ISSN 2542-193X (Online)

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Shabunina A. Y., Olomskaya V. V., Rusanova T. Y., Goryacheva I. Y. The effect of pyridoxine and its derivatives on the fluorescent properties of AgInS2/ZnS quantum dots in aqueous solutions and on the surface of polyacrylonitrile fibers. Izvestiya of Saratov University. Physics , 2026, vol. 26, iss. 2, pp. 165-174. DOI: 10.18500/1817-3020-2026-26-2-165-174, EDN: PSKIKS

This is an open access article distributed under the terms of Creative Commons Attribution 4.0 International License (CC-BY 4.0).
Published online: 
30.06.2026
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Language: 
Russian
Heading: 
Biophysics and medical physics
Article type: 
Article
UDC: 
544.723:544.723.2:535.37
DOI: 
10.18500/1817-3020-2026-26-2-165-174
EDN: 
PSKIKS

The effect of pyridoxine and its derivatives on the fluorescent properties of AgInS2/ZnS quantum dots in aqueous solutions and on the surface of polyacrylonitrile fibers

Autors: 
Shabunina Ann Yu., Saratov State University
Olomskaya Vera Vladimirovna, Saratov State University
Rusanova Tatiana Yurievna, Saratov State University
Goryacheva Irina Yurievna, Saratov State University
Abstract: 

Background and Objectives: Pyridoxine is a form of vitamin B6, a vital water-soluble vitamin with strong antioxidant properties. Mexidol and Emoxipin are domestically produced medications whose active ingredients are pyridoxine derivatives. These drugs have a broad spectrum of pharmacological effects, including antihypoxic and nootropic effects. This article proposes a method for monitoring the content of active pharmaceutical ingredients in medications based on their effect on the fluorescence of quantum dots. For pre-concentration of drugs, we propose using polyacrylonitrile fibers produced by electrospinning. These fibers promising for creating sorbents and test kits. Moreover they can be used for pre-concentration and subsequent determination of analytes. Triple quantum dots AgInS2/ZnS, which offer advantages such as bright fluorescence, biocompatibility, non-toxicity, and the ability to interact with drugs, were used to detect the concentration of active pharmaceutical ingredients. Materials and Methods: The fiber was obtained by electrospinning (voltage 70 ± 5 kV, spinning time 60 minutes, solvent dimethylformamide, current 0.02 mA). Fractions of previously synthesized 591 and 620 nm AgInS2/ZnS quantum dots were used. The effect of vitamin B6, Mexidol, and Emoxipin on the luminescent properties of the quantum dots was studied by sorption of aqueous solutions with varying drug concentrations and a constant quantum dot concentration onto polyacrylonitrile fibers. Results: For vitamin B6, the most sensitive fraction was the 620 nm quantum dot fraction applied to polyacrylonitrile fibers, and for the drug Emoxipin, the most sensitive fraction was the quantum dot fraction with a maximum of 620 nm in an aqueous solution. The action of the drugs can be described by a linear dependence of the fluorescence intensity on the concentration of the analytes (with a high value of the coefficient of determination for B6). Conclusion: Based on the decay time, it can be concluded that surface processes make the greatest contribution to the interaction between quantum dots and Mexidol. For vitamin B6 and Emoxipin with AgInS2/ZnS, the presence of electrostatic or other interactions should be investigated. The influence of excipients presents in dosage forms and the morphology of the nonwoven material require additional study.

Key words: 
polyacrylonitrile fibers
luminescence
AgInS2/ZnS quantum dots
sorption
drug detection
pyridoxine
vitamin B6
ethylmethylhydroxypyridine
ethylmethylhydroxypyridine succinate
Acknowledgments: 
This work was supported by the Russian Science Foundation (project No. 24-23-00519).
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Received: 
11.09.2025
Accepted: 
10.10.2025
Published: 
30.06.2026
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