human eye sclera

Investigation of Mildronat ® Diffusion in Human Eye Sclera

Background and Objectives: Diseases of retina and optic nerve are the major causes of vision loss. The use of new drugs in the treatment of these diseases can reduce the decline of visual function due to the involvement of additional mechanisms of cell metabolism compensation. Thus, investigation of the drug diffusion in sclera is an important task at estimation of dose necessary for achievement of enough drug concentration in internal eye tissues.

Optical Clearing of Human Eye Sclera by Aqueous 30%-Glucose Solution

In this work, optical clearing of human eye sclera in vitro under action of aqueous 30% glucose solution was studied. It was shown that diffusion of glucose in tissue results in significant decrease of light scattering, which manifests itself in both decreasing reflectance and increasing transmittance of the samples. At that, absorption coefficient does not change. Measurements were performed with spectrophotometer CARY-2415 in the spectral range from 400 to 800 nm by a standard method.