Objective: To find a way of identifying and counting of leukocytes in a native blood sample. Materials and equipments: Whole donor blood sample, digital microscop. Methods and approaches: The development of a method of leukocytes’ identification and counting for native blood samples was carried out on the basis of digital microscopy method. Main results: Leukocytes’ “highlighting” effect in a native blood sample was revealed experimentally by digital microscope examining.