Для цитирования:
Lengert E. V., Pavlov A. M. Conductive nanofibrous scaffolds for tissue engineering [Ленгерт Е. В., Павлов А. М. Проводящие нановолоконные скаффолды для тканевой инженерии] // Известия Саратовского университета. Новая серия. Серия: Физика. 2021. Т. 21, вып. 1. С. 48-57. DOI: 10.18500/1817-3020-2021-21-1-48-57, EDN: TTVLBX
Conductive nanofibrous scaffolds for tissue engineering
[Проводящие нановолоконные скаффолды для тканевой инженерии]
Одной из важных и активно развивающихся областей современной биомедицины является клеточная инженерия, исследующая вопросы выращивания новых и восстановления поврежденных тканей и органов, включая лечение травматических состояний. В природной среде клетки ткани находятся в микроокружении внеклеточного матрикса – трехмерной сети макромолеклу, в основном протеинов и пептидов, которая обеспечивает структурную и биохимическую поддержку. Для замены матрикса и поддержки роста и восстановления клеток в медицинских приложениях предложены различные типы искусственных скафаолдов. Морфология, а также физико-химические свойства скаффолдов влияют на все основные процессы в клетках, включая способность присоединяться, пролиферировать и дифференцироваться. Этот обзор призван кратко охаракеризовать существующие материалы и методы для создания скаффолдов, фокусируясь на структуры, получаемые методами электропрядения, а также скаффолды с проводящими структурами, которые могут быть использованы для передачи электрических сигналов к клеткам для их электростимуляции, которая улучшает функциональное восстановление определенных типов клеток, включая мускульные и нервные.
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