Известия Саратовского университета.

Новая серия. Серия Физика

ISSN 1817-3020 (Print)
ISSN 2542-193X (Online)

Для цитирования:

Стасенко С. В. Пачечная динамика спайковой нейронной сети, вызванная активностью внеклеточного матрикса мозга // Известия Саратовского университета. Новая серия. Серия: Физика. 2024. Т. 24, вып. 2. С. 138-149. DOI: 10.18500/1817-3020-2024-24-2-138-149, EDN: EOSDSZ

Статья опубликована на условиях лицензии Creative Commons Attribution 4.0 International (CC-BY 4.0).
Опубликована онлайн: 
28.06.2024
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Язык публикации: 
русский
Рубрика: 
Биофизика и медицинская физика
Тип статьи: 
Научная статья
УДК: 
530.182
DOI: 
10.18500/1817-3020-2024-24-2-138-149
EDN: 
EOSDSZ

Пачечная динамика спайковой нейронной сети, вызванная активностью внеклеточного матрикса мозга

Авторы: 
Стасенко Сергей Викторович, Нижегородский государственный университет имени Н. И. Лобачевского
Аннотация: 

Цель настоящей работы – исследовать влияние внеклеточного матрикса мозга на формирование пачечной динамики спайковой нейронной сети. В качестве модели нейрона использована модель нейрона Ижикевича, для описания динамики внеклеточного матрикса мозга была использована феноменологическая модель Казанцева, построенная с использованием формализма модели Ходжкина – Хаксли. Разработана и исследована модель формирования пачечной динамики спайковой нейронной сети под воздействием внеклеточного матрикса мозга. Получены основные динамические режимы нейронной активности в отсутствии регуляций и в присутствии внеклеточного матрикса мозга. Проведено исследование влияния модуляции внеклеточным матриксом мозга на частоту пачечной активности нейронной сети. В результате исследования установлено, что регуляция активности нейронов, опосредованная внеклеточным матриксом мозга, способствует группировке спайков в квазисинхронные популяционные разряды, называемые популяционными пачками. При этом увеличение силы влияния внеклеточного матрикса мозга на постсинаптические токи через синаптическое масштабирование приводит к увеличению степени синхронности популяций нейронов.

Ключевые слова: 
спайковая нейронная сеть
четырехчастный синапс
пачечная динамика
нейрон
внеклеточный матрикс мозга
Благодарности: 
Работа выполнена при финансовой поддержке Программы развития Регионального научно-образовательного математического центра «Математика технологий будущего» (Соглашение № 075-02-2024-1439).
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Поступила в редакцию: 
15.03.2024
Принята к публикации: 
02.04.2024
Опубликована: 
28.06.2024
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