Известия Саратовского университета.

Новая серия. Серия Физика

ISSN 1817-3020 (Print)
ISSN 2542-193X (Online)

Для цитирования:

Тучин В. В. Оптическая биомедицинская диагностика // Известия Саратовского университета. Новая серия. Серия: Физика. 2005. Т. 5, вып. 1. С. 39-53. DOI: 10.18500/1817-3020-2005-5-1-39-53

Статья опубликована на условиях лицензии Creative Commons Attribution 4.0 International (CC-BY 4.0).
Опубликована онлайн: 
17.11.2005
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Язык публикации: 
русский
Рубрика: 
Физика
Тип статьи: 
Научная статья
УДК: 
535+57(023)
DOI: 
10.18500/1817-3020-2005-5-1-39-53

Оптическая биомедицинская диагностика

Авторы: 
Тучин Валерий Викторович, Саратовский национальный исследовательский государственный университет имени Н. Г. Чернышевского
Аннотация: 

В работе представлен обзор работ по оптической медицинской диагностике. Кратко обсуждается история вопроса. Основное внимание уделено рассмотрению современных методов оптической медицинской диагностики, основанных на спектрофотометрии, флуоресценции, доплеровской спектроскопии, спектроскопии упругого, квазиупругого и комбинационного рассеяния, а также на использовании оптотермического и оптоакустических эффектов.

Ключевые слова: 
спектрофотометрия
флуоресценция
доплеровская спектроскопия
комбинационное рассеяние
Список источников: 
  1. Chance В. Optical method // Arm. Rev. Biophys. Biophys. Chem. 1991. V. 20. P. 1-28.
  2. Special Issue Honoring Professor Britton Chance / Eds. D. Benaron, I. Bigio, E. Sevick-Muraca, A.G. Yodh // J. Biomed. Opt. 2000. V. 5. P. 115-248; 269-282.
  3. Anderson R.R., Parrish J.A., Optical properties of human skin // The Science of Photomedicine / Eds. J.D. Regan, J.A. Parrish. N. Y., 1982. P. 147-194.
  4. Duck F.A. Physical Properties of Tissue: a Comprehensive reference book. L., 1990.
  5. Medical Optical Tomography: Functional Imaging and Monitoring / Eds. G. Mueller, B. Chance, R. Alfano et al. Bellingham: SPIE Press, 1993. V. IS 11.
  6. Selected papers on tissue optics applications in medical diagnostics and therapy / Ed. V.V. Tuchin. Bellingham: SPIE Press, 1994. V. MS 102.
  7. Patterson M.S. Noninvasive measurement of tissue optical properties: current status and future prospects // Comments Mol. Cell. Biophys. 1995.V. 8 .P. 387-417.
  8. Yodh A.G., Chance B. Spectroscopy and imaging with diffusing light // Physics Today. 1995. V. 48. P. 34-40.
  9. Das B.B., Liu F., Alfano R.R. Time-resolved fluorescence and photon migration studies in biotnedical and random media // Rep. Prog. Phys. 1997. V. 60. P. 227-292.
  10. Special Section on Clinical Near Infrared Spectroscopy/lmaging / Eds. M. Ferrari, D. Delpy, D.A. Benaron // J. Biomed. Opt. 1996. V. 1. P. 361-434; 1997. V. 2. P. 7-41; 147-175.
  11.  Selected Papers on Optical Tomography, Fundamentals and Applications in Medicine / Eds. O. Minet, G. Mueller, J. Beuthan. Bellingham: SPIE Press, 1998. V. MS 147.
  12. Okada K., Hamaoka T. Special Section on Medical NearInfrared Spectroscopy // J. Biomed. Opt. 1999. V. 4. P. 391-428.
  13. Tuchin V.V. Tissue optics: Light scattering methods and instruments for medical diagnosis // SPIE Tutorial Texts in Optical Engineering. Bellingham: SPIE Press, 2000. V. TT38.
  14. Rodriguez J., Yaroslavsky I., Yaroslavsky A. et al. Timeresolved imaging in diffusive media // Handbook of Opt. Biomed. Diagnostics / Ed. V.V. Tuchin. Bellingham: SPIE Press, 2002. V. PM107. Chap. 6.
  15. Cutler M. Transillumination as an aid in the diagnosis of breast lesions // Surg. Gynecol. Obstet. 1929. V. 48. P. 721.
  16. Millikan G.A. A simple photoelectric colorimeter // J. Physiol. (London) 1933. V. 79. P. 152-157.
  17. Il'ina A.A. Transmittance of the near infrared rays by tissues of the human body // Soviet Physiological J. 1949. V. 35. P. 338-348.
  18. Jobsis F. Non invasive monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters // Science 1977. V. 198. P. 1264-1267.
  19. Jobsis-vander Vliet F.F. Discovery of the near-infrared window into the body and the early development of nearinfrared spectroscopy // J. Biomed. Opt. 1999. V. 4. P. 392-396.
  20. Chance В., Williams G.R. A method for the localization of sites for oxidative phosphorylation // Nature (London) 1955. V. 176. P. 250-254.
  21. Chance В., Cohen P., Jobsis F., Schoener B. Intracellular oxidation-reduction states in vivo // Science 1962. V. 137. P. 499-508.
  22. Chance В., Leigh J.S., Miyake H. et al. Comparison of time-resolved and unresolved measurement of deoxygenation in tissue // Proc. Natl. Acad. Sci. USA. 1988. V. 85. P. 4971-4975.
  23. Delpy D. Т., Cope M., Van Zee P. et al. Estimation of optical path-length through tissue from direct time of flight measurement // Phys. Med. Biol. 1988. V. 33. P. 1433-1442.
  24. Patterson M.S., Chance В., Wilson B.C. Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties // Appl. Opt. 1989. V. 28. P. 2331-2336.
  25. Jacques S.L. Time-resolved reflectance spectroscopy in turbid tissues // IEEE Trans. Biomed. Eng. 1989. V. 36. P. 1155-1161.
  26. Cheong W.-F., Prahl S.A., Welch A.J. A review of the optical properties of biological tissues // IEEE J. Quantum Electr. 1990. V. 26, 2166-2185. 
  27. Quantitative Spectroscopy in Tissue / Eds. K. Frank, M. Kessler. Frankfiirt am Main: pmi-Verl., 1992.
  28. Special Issue on Optical Radiation Technique in Medicine and Biology / Ed. II. Moseley // Phys. Med. Biol. 1997. V. 24. P. 759-996.
  29. LakowiczJ.R, Berndt K. Frequency-domain measurements of photon migration in tissues // Chem. Phys. Lett. 1990. V. 166. P. 246-252.
  30. Patterson M.S., Moulton J.D., Wilson B.C. et al. Frequency-domain reflectance for the determination of the scattering and absorption properties of tissue // Appl. Opt. 1991. V. 30. P. 4474-4476.
  31. Schmitt J.M., Knuettel A., Knutson JR. Interference of diffusive light waves // J. Opt. Soc. Amer. A. 1992. V. 9. P. 1832-1843.
  32. Chance В., Cope M., Gratton E. et al. Phase measurement of light absorption and scatter in human tissue // Rev. Sci. Instrum. 1998. V. 698. P. 3457-3481. 
  33. Parrish J.A., Anderson R.R., Urbach F., Pitts D. UV-A: Biologic Effects of Ultraviolet Radiation with Emphasis on Human Responses to Longwave Ultraviolet. N. Y., 1978.
  34. Lakowicz JR. Principles of Fluorescence Spectroscopy: 2-nd ed. N. Y., 1999.
  35. Special Section on Light Scatter and Fluorescence of the Eye Lens / Ed. B.K. Pierscionek // J. Biomed. Opt. 1996. V. 1. P. 241-295.
  36. Best J.A. van, Kuppens E.V.M.J. Summary of studies on the blue - green autofluorescence and light transmission of the ocular lens //J. Biomed. Opt. 1996. V. 1. P. 243-250. 
  37. Yu N.-T., Krantz B.S., Eppstein J.A. et al. Development of noninvasive diabetes screening device using the ratio of fluorescence to Rayleigh scattered light // J. Biomed. Opt. 1996. V.I. P. 280-288.
  38. Denk W. Two-photon excitation in functional biological imaging//J. Biomed. Opt. 1996. V. 1. P. 296-304.
  39. Ozaki Y., Medical application of Raman spectroscopy // Appl. Spectroscopy Reviews. 1988. V. 24. P. 259-312. 
  40. Tu A.T. Raman Spectroscopy in Biology. N. Y., 1982.
  41. Mahadevan-Jansen A., Richards-Kortum R. Raman spectroscopy for detection of cancers and precancers // J. Biomed. Opt. 1996. V. 1. P. 31-70.
  42. Special Section on Biomedical Applications of Vibrational Spectroscopic Imaging / Ed. M.D. Morris // J. Biomed. Opt. 1999. V. 4. P. 6-34.
  43. Carden A., Morris M.D. Application of vibration spectroscopy to the study of mineralized tissues (review) // J. Biomed. Opt. 2000. V. 5. P. 259-268.
  44. McNichols R. J., Cote G.L. Optical glucose sensing in biological fluids: an overview // J. Biomed. Opt. 2000. V. 5. P. 5-16. 
  45. Lucassen G.W., Veen G.N.A. van, Jansen J.A.J. Band analysis of hydrated human skin stratum corneum attenuated total reflectance Fourier transform infrared spectra in vivo // J. Biomed. Opt. 1998. V. 3. P. 267-280. 
  46. Perelman L. Т., Backman V., Wallace M. et al. Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution // Phys. Rev. Lett 1998. V. 80. P. 627-630.
  47. Photon Correlation and Light Beating Spectroscopy / Eds. H.Z. Cummins, E.R. Pike. N. Y., 1974; Photon Correlation Spectroscopy and Velocimetry, N. Y., 1977. 
  48. Tuchin V. V. Coherence-domain methods in tissue and cell optics // Laser Physics. 1998. V. 8. P. 807-849.
  49. Tuchin V. V. Coherent optical techniques for the analysis of tissue structure and dynamics // J. Biomed. Opt. 1999. V. 4. P. 106-124.
  50. Special Section on Optical Diagnostics of Biological Fluids / Eds. A.V. Priezzhev, T. Asakura // J. Biomed. Opt. 1999. V. 4. P. 35-93. 
  51. Special Section on Coherence Domain Optical Methods in Biomedical Science and Clinics / Eds. V.V. Tuchin, H. Podbieiska, C.K. Hitzenberger // J. Biomed. Opt. 1999. V. 4. P. 94-190. 
  52. Braslavsky S.E., HeihoffK. Photothermal methods // Handbook of Organic Photochemistry / Ed. J.C. Scaiano. Boca Raton: CRC Press, 1989. 
  53. Gusev V.E., Karabutov A.A. Laser Optoacoustics. N. Y., 1993.
  54. Tuchin V. V. Lasers and fiber optics in biomedicine // Laser Physics. 1993. V. 3. P. 767-820; 925-950. 
  55. Heusmann H., Kolzer J., Mitic G. Characterization of female breast in vivo by time resolved and spectroscopic measurements in near infrared spectroscopy // J. Biomed. Opt. 1996. V. 1. P. 425-434.
  56. Luo Q., Zeng S., Chance В., Nioka S. Monitoring of brain activity with near infrared spectroscopy // Opt. Biomed. Diagnostics / Ed. V.V. Tuchin. Bcllingham: SPIE Press, 2001. Chap. 8.
  57. Matcher S.J. Absolute quantification in tissue near-infrared spectroscopy // Handbook of Opt. Biomed. Diagnostics / Ed. V.V. Tuchin. Bellingham: SPIE Press, 2001. Chap. 9.
  58. Bigio I.J., Mourant J.R. Ultraviolet and visible spectroscopies for tissue diagnostics: fluorescence spectroscopy and elastic-scattering spectroscopy // Phys. Mcd. Biol. 1997. V. 42. P. 803-814.
  59. Sacks Z.S., Craig D.L, Kurtz R.M. et al. Spatially resolved transmission of highly focused beams through cornea and sclera between 1400 and 1800 nm // Proc. SPIE. 1999. V. 3726. P. 522-527.
  60. Berg T..J.T.P. van den, Tan K.E.W.P. Light transmittance of the human cornea from 320 to 700 nm for different ages // Vision Res. 1994. V. 33. P. 1453-1456.
  61. Dillon J. '1Ъе photophysics and photobiology of the eye // J. Photochem. Photobiol. B: Biol. 1991. V. 10. P 23-40.
  62. Fishkin J.B., Gratton E. Propagation of photon-density waves in strongly scattering media containing an absorbing semi-infinite plane bounded by a strait edge // J. Opt. Soc. Amer. A. 1993. V. 10. P. 127-140.
  63. Fishkin J.B., Coquoz O., Anderson E.R. et al. Frequencydomain photon migration measurements of normal and malignant tissue optical properties in a human subject // Appl. Opt. 1997. V. 36. P. 10-20.
  64. Tromberg В., Coquoz O., Fishkin J.B. et al Non-invasive measurements of breast tissue optical properties using frequency-domain photon migration // Phil. Trans. R. Soc. Lond. B. 1997. V. 352. P. 661-668.
  65. Schneckenburger H., Steiner R., Strauss W., Stock K., Sailer R. Fluorescence technologies in biomedical diagnostics // Handbook of Opt. Biomed. Diagnostics / Ed. V.V. Tuchin. Bellingham: SPIE Press, 2002. Chap. 15.
  66. Sinichkin Yu.P., Kollias N., Zonios G. et al. Reflectance and fluorescence spectroscopy of human skin in vivo II Handbook of Opt. Biomed. Diagnostics / Ed. V.V. Tuchin. Bellingham: SPIE Press, 2002. Chap. 13.
  67. Svanberg S. New developments in laser medicine // Phys. Scripta. 1997. V. 72. P. 69-75.
  68. Richards-Kortum R.R., Rava R.P., Petras R.E. et al. Spectroscopic diagnosis of colonic dysplasia // Photochem. Photobiol. 1991. V. 53. P. 777-786.
  69. Sterenborg H.J.C.M., Motamedi M., Wagner R.F. In vivo fluorescence spectroscopy and imaging of human skin tumors // Lasers Med. Sci. 1994. V. 9. P. 344-348.
  70. Zeng H., MacAulay C, McLean D. I. et al. Spectroscopic and microscopic characteristics of human skin autofluorescence emission // Photochem. Photobiol. 1995. V. 61. P. 639-645.
  71. Sinichkin Yu.P., Utz S.R., MavlutovA.il, Pilipenko H.A. In vivo fluorescence spectroscopy of the human skin: experiments and models // J. Biomed. Opt. 1998. V. 3. P. 201-211.
  72. Malik 7.., Amit I, Rothmann С Subcellular localization of sulfonated tetraphenyl porphines in colon carcinoma cells by spectrally resolved imaging // Photochem. Photobiol. 1997. V. 65. P. 389-396.
  73. Lucassen G.W., Caspers P.J., Puppels G.J. Infrared and Raman spectroscopy of human skin in vivo II Handbook of Opt. Biomed. Diagnostics / Ed. V.V. Tuchin. Bellingham: SPIE Press, 2002. V. PM107. Chap. 14.
  74. Puppels G.J. Confocal Raman microspectroscopy // Fluorescent and luminescent probes for biological activity / Ed. W. Mason. L., 1999. P. 377^106.
  75. Perelman L.T., Backman V, Light scattering spectroscopy of epithelial tissues: principles and applications // Handbook of Opt. Biomed. Diagnostics / Ed. V.V. Tuchin. Bellingham: SPIE Press, 2002. V. PM107. Chap. 12.
  76. Mourant J.R., Freyer J.P., Hielscher A.H. et al. Mechanisms of light scattering from biological cells relevant to noninvasive optical-tissue diagnosis // Appl. Opt. 1998. V. 37. P. 3586-3593.
  77. Drezek R., Dunn A., Richards-Kortum R. Light scattering from cells: finite-difference time-domain simulations and goniometric measurements // Appl. Opt. 1999. V. 38. P. 3651-3661.
  78. Backman V., Wallace M, Perelman L.I', et al. Diagnosing Cancers Using Spectroscopy // Nature. 2000. V. 406. № 6791. P. 35-36.
  79. Bohren C.F., Huffman DR. Absorption and Scattering of Light by Small Particles. N. Y., 1983.
  80. Yang C, Perelman L.T., Wax A. et al. Feasibility of fieldbased light scattering spectroscopy // J. Biomed. Opt. 2000. V. 5. P. 138-143.
  81. Morgner U., Drexler W., Kartner F.X. el al. Spectroscopic optical coherence tomography // Optics Lett. 2000. V. 25. P. 111-113.
  82. Backman V., Gurjar R., Badizadegan K. et al. Polarized light scattering spectroscopy for quantitative measurement of epithelial cellular structures in situ II IEEE J. Sel. Top. Quant. Elect. 1999. V. 5. P. 1019-1026.
  83. Oraevsky A.A., Jacques S.J., Tittel F.K. Measurement of tissue optical properties by time-resolved detection of laserinduced transient stress // Appl. Opt. 1997. V. 36. P. 402-415.
  84. Sathyam U.S., Prahl S.A. Limitations in measurement of subsurface temperatures using pulsed photothermal radiometry // J. Biomed. Opt. 1997. V. 2. P. 251-261.
  85. Milner Т.Е., Goodman D.M., Tanenbaum B.S. et al. Noncontact determination of thermal diffusivity in biomatcrials using infrared imaging radiometry // J. Biomed. Opt. 1996. V. 1. P. 92-97.
  86. Приезжее А.В., Тучин ВВ., Шубочкин Л.П. Лазерная диагностика в биологии и медицине. М., 1989.
  87. Тучин ВВ. Лазеры и волоконные световоды в биомедицинских исследованиях. Саратов, 1998.
  88. Tuchin V. V. Handbook of Optical Biomedical Diagnostics., Bellingham: SPIE Press, 2002. V. PM107
  89. Tuchin V. V. Biomedical Spectroscopy // Encyclopedia of Optical Engineering. Marcel Dekker, Inc., USA, 2003.
  90. Tuchin V.V. Tissue Spectroscopy // Encyclopedia of Optical Engineering, Marcel Dekker, Inc., 2003.
  91. Tuchin V.V. Light-Tissue Interactions // Biomedical Photonics Handbook. Boca Raton: CRC Press, 2003.
  92. Zimnyakov D.A., Tuchin V.V. Speckle Correlometry // Biomedical Photonics Handbook. Boca Raton: CRC Press, 2003.
  93. Coherent-Domain Optical Methods for Biomedical Diagnostics, Environmental and Material Science / Ed. V.V. Tuchin. Boston, USA, 2004. V. 1-2.
  94. Tuchin V.V., Lihong Wang, ZimnyakovD. Optical Polarization in Biomedical Applications. Boston: Springer-Verlag, 2006 (in press). 
Поступила в редакцию: 
02.06.2005
Принята к публикации: 
12.10.2005
Опубликована: 
17.11.2005
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