Biophysics and medical physics

Investigation of Mildronat ® Diffusion in Human Eye Sclera

Background and Objectives: Diseases of retina and optic nerve are the major causes of vision loss. The use of new drugs in the treatment of these diseases can reduce the decline of visual function due to the involvement of additional mechanisms of cell metabolism compensation. Thus, investigation of the drug diffusion in sclera is an important task at estimation of dose necessary for achievement of enough drug concentration in internal eye tissues.

Processing and Visualization of Large Data Arrays in Taxonomic and Evolutionary Studies of Living Nature1 (a review)

A review is given of recent advances in the taxonomic study of organisms and current views on biological evolution and the origin of life. The steady increase in bioinformation resources is noted, which reflects the results of studies of the Earth’s biodiversity with the use of deciphered structures of biomacromolecules (DNA, RNA, proteins, etc.). This necessitates accounting for the specific character of manipulations with large data arrays, which is currently termed the big data problem.

Study of Ethanol Impact on the Transepidermal Transport of Indocyanine Green with Backscattering Spectroscopy

In the work, impact of aqueous 40%-ethanol solution on the transepidermal transport of photodynamic dye indocyanine green has been studied with backscattering spectroscopy. It has been first obtained the value of the dye diffusion coefficient through the stratum corneum ex vivo at the use of ethanol as a diffusion enhancer: (6.85±3.75)×10−7 cm2/s.