Izvestiya of Saratov University.


ISSN 1817-3020 (Print)
ISSN 2542-193X (Online)

For citation:

Agafonov D. N., Timoshina P. A., Vilensky M. A., Fedosov I. V., Tuchin V. V. The Study of Nail Bed Microcirculation by Laser SpeckleImaging Technique. Izvestiya of Saratov University. Physics , 2011, vol. 11, iss. 2, pp. 14-19. DOI: 10.18500/1817-3020-2011-11-2-14-19

This is an open access article distributed under the terms of Creative Commons Attribution 4.0 International License (CC-BY 4.0).
Full text:
(downloads: 132)

The Study of Nail Bed Microcirculation by Laser SpeckleImaging Technique

Agafonov Dmitry Nikolaevich, Saratov State University
Timoshina Polina Aleksandrovna, Saratov State University
Vilensky Maxim Alekseevich, Saratov State University
Fedosov Ivan Vladenovich, Saratov State University
Tuchin Valery Viсtorovich, Science Medical Center, Saratov State University

The applicability of laser speckle contrast analysis technique for study of nail bed microcirculation parameters was investigated. Parameters and their dynamics were considered using calibration data obtained with biotissue phantom. Optimal conditions of formation and registration of speckle images were discussed and program for adaptive operation and processing was presented. The data of microscopic observations of nail bed capillary network was used to verify the results of speckle visualization.

  1. Hern S., Mortimer P. S. Visualization of dermal blood vessels – capillaroscopy // Clin. Exp. Dermatol. 1999. Vol. 24. P. 473–478.
  2. Виленский М. А., Агафонов Д. Н., Зимняков Д. А., Тучин В. В., Здражевский Р. А. Спекл-корреляционный анализ микрокапиллярного кровотока ногтевого ложа // Квант. электроника. 2011. Т. 41, № 4. С. 324–328.
  3. Bukhari M., Herrick A. L., Moore T., Manning J., Jayson M. I. V. Increased nailfold capillary dimensions in primary Raynaud’s phenomenon and systemic sclerosis // Br. J. Rheum. 1996. Vol. 35. P. 1127–1131.
  4. Briers J. D., Webster S. Laser speckle contrast analysis (LASCA) : a non-scanning, full-fi eld technique for monitoring capillary blood fl ow // J. Biomed. Opt. 1996. Vol. 1. P. 174–179.
  5. Luo Q., Qiu J., Li P. Blood fl ow cytometry and cell aggregation study with laser speckle // Advanced optical fl ow cytometry : methods and disease diagnoses / ed. V. V. Tuchin. Weinheim : Wiley-VCH Verlag GmbH & Co. KGaA, 2011. 734 p.
  6. Briers J.D. Laser Doppler, speckle and related techniques for blood perfusion mapping and imaging // Physiol. Meas. 2001. Vol. 22. P. R35–R66.
  7. Boas D.A., Dunn A.K. Laser speckle contrast imaging in biomedical optics // J. Biomed. Opt. 2010. Vol. 15(1). P. 011109.
  8. Duncan D.D., Kirkpatrick S.J. Can laser speckle fl owmetry be made a quantitative tool? // J. Opt. Soc. Amer. A : Opt. Image Sci. Vis. 2008. Vol. 25(8). P. 2088–2094.
  9. Tuchin V. V. Optical Clearing of Tissues and Blood. Bellingham : SPIE Press, 2006. 254 р.
  10. Zhu D., Wang J., Zhi Z., Wen X., Luo Q. Imaging dermal blood fl ow through the intact rat skin with an optical clearing method // J. Biomed. Opt. 2010. Vol. 15. P. 026008.