Izvestiya of Saratov University.

Physics

ISSN 1817-3020 (Print)
ISSN 2542-193X (Online)

For citation:

Kalyanov A. L., Malinova L. I., Bogolyubova E. V., Smirnov I. V., Lychagov V. V., Ryabukho V. P. Investigation of «Erythrocyte – Plasma» Complex in Native Human Blood Slide Using WhiteLight FullField Microinterferometry. Izvestiya of Saratov University. Physics , 2011, vol. 11, iss. 2, pp. 19-24. DOI: 10.18500/1817-3020-2011-11-2-19-24

This is an open access article distributed under the terms of Creative Commons Attribution 4.0 International License (CC-BY 4.0).
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Language: 
Russian
Heading: 
Physics
UDC: 
535.417: 616.379008.64
DOI: 
10.18500/1817-3020-2011-11-2-19-24

Investigation of «Erythrocyte – Plasma» Complex in Native Human Blood Slide Using WhiteLight FullField Microinterferometry

Autors: 
Kalyanov Aleksandr Leont'evna, Saratov State University
Malinova Lydia Igorevna, FSI "Saratov Research Institute of Cardiology" of the Ministry of Health and Social Development of the Russian Federation
Bogolyubova Elena Vladimirovna, Saratov State University
Smirnov Ilya Vladimirovich, Saratov State University
Lychagov Vladislav Valer'evich, Saratov State University
Ryabukho Vladimir Petrovich, Saratov State University
Abstract: 

Morphofunctional properties of erythrocytes in native blood slide of coronary heart disease patients are investigated using white light fullfield microinterferometry. Three dimensional images and surface profiles of complex «single RBC – surrounding blood plasma» are shown. Dynamic of slope angle of the plasma near the RBC during standardized intravenous glucose load is explored. The dynamic of patients with coronary heart disease is compared with one of patients with coronary heart disease and diabetes mellitus.

Key words: 
low-coherence interferometry
full-field interferometry
interference microscopy
morphofunctional properties of erythrocyte
perfusion
coronary heart disease
diabetes mellitus
Reference: 
  1. Fuller J. H., Shipley M. J., Rose G., Jarrett R. J., Keen H. Mortality from coronary heart disease and stroke in relation to degree of glycaemia : the Whitehall study // Br. Med. J. (Clin. Res. Ed.). 1983. Vol. 287. P. 867–870.
  2. Balkau B., Shipley M., Jarrett R.J., Pyorala K., Pyorala M., Forhan A., Eschwege E. High blood glucose concentration is a risk factor for mortality in middle-aged nondiabetic men. 20-year follow-up in the Whitehall Study, the Paris Prospective Study, and the Helsinki Policemen Study // Diabetes Care. 1998. Vol. 21. P. 360–367.
  3. Butter W. J., Ostrander L. D., Carman W. J., Lamphier D. E. Mortality from coronary heart disease in the Tecumseh study. Long-term effect of diabetes mellitus, glucose tolerance and other risk factors // Amer. J. Epidemiol. 1985. Vol. 121. P. 541–547.
  4. Haffner S. M., Mykkanen L., Festa A., Burke J. P., Stern M. P. Insulin-resistant prediabetic subjects have more atherogenic risk factors than insulin-sensitive prediabetic subjects : implications for preventing coronary heart disease during the prediabetic care // Circulation. 2000. Vol. 101. P. 975–980.
  5. Brownlee M., Cerami A., Vlassara H. Advanced glycosilation end products in tissue and the biochemical basis of diabetic complications // N. Engl. J. Med. 1988. Vol. 318. P. 1315–1321.
  6. Baynes J. W. Role of oxidative stress in development of complications in diabetes // Diabetes. 1991. Vol. 40. P. 405–412.
  7. Schmidt A. M., Hori O., Cao R., Yan S. D. Brett J., Wautier J. L., Ogawa S., Kuwabara K., Matsumoto M., Stern D. RAGE : a novel cellular receptor for advanced glycation end products // Diabetes. 1996. Vol. 45. Suppl. 3. P. S77–80.
  8. Бондарь Т. П., Козинец Г. И. Морфофункциональное состояние эритроцитов периферической крови при поздних сосудистых осложнениях сахарного диабета типа 2 (обзор литературы) // Клин. лаб. диагн. 2002. № 12. С. 22–34.
  9. Кравец Е. Б., Колосова М. В., Новицкий В. В., Стеновая Е. А. Белковый спектр и состояние липидного бислоя мембран эритроцитов у детей с инсулинзависимым сахарным диабетом (по данным электрофореза в полиакриламидном геле и флюоресцентного анализа) // Бюл. экспер. биол. 2000. № 3. С. 306–309.
  10. Ефимов А. С. Диабетические ангиопатии. М., 1989. 169 с.
  11. Optical coherence tomography : technology and applications / eds. W. Drexler, J. G. Fujimoto. New York : Springer, 2008. 1330 p.
  12. Лычагов В. В., Кальянов А. Л., Рябухо В. П. Низкокогерентная микроинтерферометрия внутренней структуры кристаллизовавшейся плазмы крови // Опт. и спектр. 2009. Т. 107, № 6. С. 909–916.
  13. Dubois A., Vabre L., Boccara A., Beaurepaire E. Highresolution full-fi eld optical coherence tomography with a Linnik microscope // Appl. Opt. 2002. Vol. 41, №. 4. P. 805–812.
  14. Вишняков Г. Н., Левин Г. Г., Минаев В. Л. Томографическая микроскопия трехмерных фазовых объектов в частично когерентном свете // Опт. и спектр. 2003. Т. 95, № 1. С. 142–146.
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